Matches in SemOpenAlex for { <https://semopenalex.org/work/W206548540> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W206548540 abstract "N-substituted BZT analogs with high dopamine transporter (DAT) affinity and slow onsets of effect decreased cocaine self administration (SA) in rats (JPET 329:677). The present study examined additional N-substituted 4′,4″-diF-BZT selective DAT inhibitors, with DAT affinities of 5.59 to 29.2 nM, and relatively faster onsets of action [JHW 013 (N-methyl-cyclopropyl-diF-BZT), GA 1–69 (N-ethyl-3-indole-diF-BZT), GA 2–50 (N-(R)-2″-amino-3″-methyl-n-butyl-diF-BZT) and GA 2–99 (N-2″-aminoethyl-diF-BZT)]. Rats were trained with cocaine SA (0.032–1.0 mg/kg/injection, IV) under fixed-ratio 5-response schedules of reinforcement. Maximal response rates were maintained by 0.32 mg/kg/inj of cocaine or by a standard DAT inhibitor, nomifensine (0.1 mg/kg/inj) when substituted for cocaine. Lower response rates were maintained at higher and lower doses. Responding was virtually eliminated when responses did not produce injections, and none of the BZT analogs maintained responding above those levels. Pretreatment (IP) with nomifensine dose-dependently shifted the cocaine SA dose-effect curve leftward. In contrast, the BZT analogs (IP) dose-dependently decreased cocaine SA at lower doses than those that decreased response rates maintained by food reinforcement. The present study further supports the development of N-substituted BZT analogs as medications to treat cocaine abuse. Supported by NIDA IRP." @default.
- W206548540 created "2016-06-24" @default.
- W206548540 creator A5010869299 @default.
- W206548540 creator A5025423982 @default.
- W206548540 creator A5061926206 @default.
- W206548540 creator A5067428741 @default.
- W206548540 date "2010-04-01" @default.
- W206548540 modified "2023-09-24" @default.
- W206548540 title "Evaluation of N‐Substituted Benztropine (BZT) Analogs for Cocaine Antagonist Effects in Rats Trained to Self‐Administer Cocaine" @default.
- W206548540 doi "https://doi.org/10.1096/fasebj.24.1_supplement.765.6" @default.
- W206548540 hasPublicationYear "2010" @default.
- W206548540 type Work @default.
- W206548540 sameAs 206548540 @default.
- W206548540 citedByCount "0" @default.
- W206548540 crossrefType "journal-article" @default.
- W206548540 hasAuthorship W206548540A5010869299 @default.
- W206548540 hasAuthorship W206548540A5025423982 @default.
- W206548540 hasAuthorship W206548540A5061926206 @default.
- W206548540 hasAuthorship W206548540A5067428741 @default.
- W206548540 hasConcept C126322002 @default.
- W206548540 hasConcept C137183658 @default.
- W206548540 hasConcept C170493617 @default.
- W206548540 hasConcept C185592680 @default.
- W206548540 hasConcept C2776755682 @default.
- W206548540 hasConcept C2776885963 @default.
- W206548540 hasConcept C2777078754 @default.
- W206548540 hasConcept C2778555786 @default.
- W206548540 hasConcept C2908949072 @default.
- W206548540 hasConcept C2910393698 @default.
- W206548540 hasConcept C513476851 @default.
- W206548540 hasConcept C55493867 @default.
- W206548540 hasConcept C71924100 @default.
- W206548540 hasConcept C98274493 @default.
- W206548540 hasConceptScore W206548540C126322002 @default.
- W206548540 hasConceptScore W206548540C137183658 @default.
- W206548540 hasConceptScore W206548540C170493617 @default.
- W206548540 hasConceptScore W206548540C185592680 @default.
- W206548540 hasConceptScore W206548540C2776755682 @default.
- W206548540 hasConceptScore W206548540C2776885963 @default.
- W206548540 hasConceptScore W206548540C2777078754 @default.
- W206548540 hasConceptScore W206548540C2778555786 @default.
- W206548540 hasConceptScore W206548540C2908949072 @default.
- W206548540 hasConceptScore W206548540C2910393698 @default.
- W206548540 hasConceptScore W206548540C513476851 @default.
- W206548540 hasConceptScore W206548540C55493867 @default.
- W206548540 hasConceptScore W206548540C71924100 @default.
- W206548540 hasConceptScore W206548540C98274493 @default.
- W206548540 hasIssue "S1" @default.
- W206548540 hasLocation W2065485401 @default.
- W206548540 hasOpenAccess W206548540 @default.
- W206548540 hasPrimaryLocation W2065485401 @default.
- W206548540 hasRelatedWork W1949132984 @default.
- W206548540 hasRelatedWork W1969008137 @default.
- W206548540 hasRelatedWork W1977182351 @default.
- W206548540 hasRelatedWork W1988606035 @default.
- W206548540 hasRelatedWork W1989459745 @default.
- W206548540 hasRelatedWork W2025483729 @default.
- W206548540 hasRelatedWork W2051082957 @default.
- W206548540 hasRelatedWork W2074555108 @default.
- W206548540 hasRelatedWork W2086045690 @default.
- W206548540 hasRelatedWork W2608551923 @default.
- W206548540 hasVolume "24" @default.
- W206548540 isParatext "false" @default.
- W206548540 isRetracted "false" @default.
- W206548540 magId "206548540" @default.
- W206548540 workType "article" @default.