Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065486527> ?p ?o ?g. }
- W2065486527 endingPage "343" @default.
- W2065486527 startingPage "330" @default.
- W2065486527 abstract "Satellite cells are myogenic progenitors that reside on the myofiber surface and support skeletal muscle repair. We used mice in which satellite cells were detected by GFP expression driven by nestin gene regulatory elements to define age-related changes in both numbers of satellite cells that occupy hindlimb myofibers and their individual performance. We demonstrate a reduction in satellite cells per myofiber with age that is more prominent in females compared to males. Satellite cell loss also persists with age in myostatin-null mice regardless of increased muscle mass. Immunofluorescent analysis of isolated myofibers from nestin–GFP/Myf5nLacZ/+ mice reveals a decline with age in the number of satellite cells that express detectable levels of βgal. Nestin–GFP expression typically diminishes in primary cultures of satellite cells as myogenic progeny proliferate and differentiate, but GFP subsequently reappears in the Pax7+ reserve population. Clonal analysis of sorted GFP+ satellite cells from hindlimb muscles shows heterogeneity in the extent of cell density and myotube formation among colonies. Reserve cells emerge primarily within high-density colonies, and the number of clones that produce reserve cells is reduced with age. Thus, satellite cell depletion with age could be attributed to a reduced capacity to generate a reserve population." @default.
- W2065486527 created "2016-06-24" @default.
- W2065486527 creator A5003360971 @default.
- W2065486527 creator A5004882158 @default.
- W2065486527 creator A5008173187 @default.
- W2065486527 creator A5078883681 @default.
- W2065486527 date "2010-04-01" @default.
- W2065486527 modified "2023-10-03" @default.
- W2065486527 title "The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny" @default.
- W2065486527 cites W1497122637 @default.
- W2065486527 cites W1641750848 @default.
- W2065486527 cites W1965982769 @default.
- W2065486527 cites W1967533362 @default.
- W2065486527 cites W1973936566 @default.
- W2065486527 cites W1974508591 @default.
- W2065486527 cites W1974703394 @default.
- W2065486527 cites W1977213772 @default.
- W2065486527 cites W1977233815 @default.
- W2065486527 cites W1982174586 @default.
- W2065486527 cites W1986973204 @default.
- W2065486527 cites W1988393390 @default.
- W2065486527 cites W1992050281 @default.
- W2065486527 cites W1994254900 @default.
- W2065486527 cites W1995215567 @default.
- W2065486527 cites W2015332685 @default.
- W2065486527 cites W2015980237 @default.
- W2065486527 cites W2016685492 @default.
- W2065486527 cites W2018659964 @default.
- W2065486527 cites W2019755200 @default.
- W2065486527 cites W2022487205 @default.
- W2065486527 cites W2022779867 @default.
- W2065486527 cites W2023585072 @default.
- W2065486527 cites W2023787917 @default.
- W2065486527 cites W2029914169 @default.
- W2065486527 cites W2031145230 @default.
- W2065486527 cites W2031495223 @default.
- W2065486527 cites W2033244461 @default.
- W2065486527 cites W2040004746 @default.
- W2065486527 cites W2042975342 @default.
- W2065486527 cites W2044110964 @default.
- W2065486527 cites W2047754931 @default.
- W2065486527 cites W2048134135 @default.
- W2065486527 cites W2049193450 @default.
- W2065486527 cites W2049432588 @default.
- W2065486527 cites W2053079324 @default.
- W2065486527 cites W2060248060 @default.
- W2065486527 cites W2061434701 @default.
- W2065486527 cites W2066123991 @default.
- W2065486527 cites W2070667194 @default.
- W2065486527 cites W2077747718 @default.
- W2065486527 cites W2077802763 @default.
- W2065486527 cites W2079643152 @default.
- W2065486527 cites W2083297650 @default.
- W2065486527 cites W2083409148 @default.
- W2065486527 cites W2087803244 @default.
- W2065486527 cites W2088043742 @default.
- W2065486527 cites W2090671494 @default.
- W2065486527 cites W2092397904 @default.
- W2065486527 cites W2093355627 @default.
- W2065486527 cites W2095606469 @default.
- W2065486527 cites W2096226963 @default.
- W2065486527 cites W2098072804 @default.
- W2065486527 cites W2100250587 @default.
- W2065486527 cites W2105071743 @default.
- W2065486527 cites W2106562809 @default.
- W2065486527 cites W2108567185 @default.
- W2065486527 cites W2112473132 @default.
- W2065486527 cites W2116005079 @default.
- W2065486527 cites W2118942329 @default.
- W2065486527 cites W2119032894 @default.
- W2065486527 cites W2122059149 @default.
- W2065486527 cites W2124153237 @default.
- W2065486527 cites W2143587612 @default.
- W2065486527 cites W2170709040 @default.
- W2065486527 cites W2253568583 @default.
- W2065486527 cites W2323748919 @default.
- W2065486527 doi "https://doi.org/10.1016/j.ydbio.2010.01.006" @default.
- W2065486527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2854302" @default.
- W2065486527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20079729" @default.
- W2065486527 hasPublicationYear "2010" @default.
- W2065486527 type Work @default.
- W2065486527 sameAs 2065486527 @default.
- W2065486527 citedByCount "187" @default.
- W2065486527 countsByYear W20654865272012 @default.
- W2065486527 countsByYear W20654865272013 @default.
- W2065486527 countsByYear W20654865272014 @default.
- W2065486527 countsByYear W20654865272015 @default.
- W2065486527 countsByYear W20654865272016 @default.
- W2065486527 countsByYear W20654865272017 @default.
- W2065486527 countsByYear W20654865272018 @default.
- W2065486527 countsByYear W20654865272019 @default.
- W2065486527 countsByYear W20654865272020 @default.
- W2065486527 countsByYear W20654865272021 @default.
- W2065486527 countsByYear W20654865272022 @default.
- W2065486527 countsByYear W20654865272023 @default.
- W2065486527 crossrefType "journal-article" @default.
- W2065486527 hasAuthorship W2065486527A5003360971 @default.
- W2065486527 hasAuthorship W2065486527A5004882158 @default.