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• W2065487497 startingPage "17" @default.
• W2065487497 abstract "Objectives: Analysis of immune response in HIV controllers, a unique group of infected individuals who are able to control HIV naturally, has provided us a chance to investigate the roles of host immune responses in HIV control. Design: In this study, the functional quality of HIV Gag p24-specific CD8+ T-cell responses was assessed in two groups of clinically distinct, HLA-B*27, HLA-B*57/58-matched individuals, viremic controllers [plasma HIV load (pVL) ≤2000 copies/ml) and noncontrollers (pVL >2000 copies/ml) to determine its impacts on natural HIV clinical outcome. Methods: An ex-vivo interferon (IFN)-γ ELISpot assay was used to screen for each individual's HIV Gag p24-specific T-cell responses. Intracellular cytokine staining assay was used to determine their functional quality (as number of cytokine being produced). Results: We found that, in contrast to previous studies, all Thai volunteers with HLA-B*5801 were uniformly noncontrollers. Viremic controllers were observed with a significantly larger number of high functional quality p24-specific CD8+ T cells than noncontrollers (P < 0.05). This superior quality of responses was observed at both total p24 and epitope-specific level. Moreover, the absolute number of high functional quality Gag p24-specific CD8+ T cells was significantly in a negative correlation with pVL (r = −0.6984, P = 0.0006) and also in a positive correlation with CD4+ T-cell count (r = 0.5648, P = 0.0095). Conclusion: We concluded that an adequate number of high functional quality Gag p24-specific CD8+ T cells is strongly associated with a natural HIV controller status." @default.
• W2065487497 created "2016-06-24" @default.
• W2065487497 creator A5024225057 @default.
• W2065487497 creator A5037724112 @default.
• W2065487497 creator A5061801780 @default.
• W2065487497 date "2013-01-02" @default.
• W2065487497 modified "2023-09-26" @default.
• W2065487497 title "Poor HIV control in HLA-B*27 and B*57/58 noncontrollers is associated with limited number of polyfunctional Gag p24-specific CD8+ T cells" @default.
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• W2065487497 doi "https://doi.org/10.1097/qad.0b013e32835ac0e1" @default.
• W2065487497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23079801" @default.
• W2065487497 hasPublicationYear "2013" @default.
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