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- W2065499535 abstract "Abstract One-electron oxidation of silybin, a flavonoid drug used in human therapy of liver, was investigated by pulse radiolysis at neutral pH. Phenoxyl radicals formed from the substrate by oxidising N . 3 radicals were identified by comparing the transient optical absorption spectra with those obtained from model compounds. The orto-methoxy-phenolic structure (ring B) is the exclusive target for one-electron oxidation of silybin. The 5.7-dihydroxy-chromanone moiety (ring A) withstands free-radical attack at neutral pH due to the chelatic H-bond (p K a = 10.2) existing between the 5-OH and 4-oxo groups. Hydroxyl radicals react with silybin at diffusion controlled rate ( k = 1.8 x 10 10 dm 3 mol -1 s -1 ). The reactivity of silybin towards free radicals at neutral pH is conform with the assumption that the physiological activity of the flavonoid is due to its chain-breaking antioxidant behaviour." @default.
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- W2065499535 date "1992-01-01" @default.
- W2065499535 modified "2023-09-24" @default.
- W2065499535 title "Pulse radiolysis of silybin: One-electron oxidation of the flavonoid at neutral pH" @default.
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- W2065499535 doi "https://doi.org/10.1016/1359-0197(92)90177-h" @default.
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