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- W2065527144 abstract "Thalamotomy for medically refractory Parkinson's disease (PD) is considered to be efficacious and relatively safe. Because a minority of patients experience decrements in language and memory (often mild and transient) after thalamotomy, chronic thalamic deep brain stimulation (DBS) might be a safer treatment given its reversibility and the modifiability of stimulation parameters. Two preliminary studies support the relative cognitive safety of unilateral DBS of the ventral intermediate (Vim) thalamic nucleus, but it is unclear whether possibly subtle changes in language and memory represent effects of microthalamotomy or of stimulation per se. This report provides preliminary data concerning effects of left thalamic stimulation on information processing speed, semantic memory (verbal fluency and visual confrontation naming), and verbal episodic memory in a patient with PD. In addition to being evaluated before and 3 and 6 months after surgery, the patient was tested 18 months after surgery either on or off medications and with the stimulator turned either on or off (order counterbalanced across medication conditions). Test performance differences between the stimulation conditions were attenuated off as compared to on medication. Vim stimulation consistently, albeit subtly, improved semantic verbal fluency but interfered with immediate recall of word lists. Parallels to findings from acute, intraoperative thalamic stimulation studies are explored. The hypothesis is offered that left Vim stimulation might facilitate access to semantic memory, but interfere with episodic memory processes." @default.
- W2065527144 created "2016-06-24" @default.
- W2065527144 creator A5005279477 @default.
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- W2065527144 creator A5056978596 @default.
- W2065527144 creator A5075896621 @default.
- W2065527144 date "1998-11-01" @default.
- W2065527144 modified "2023-10-04" @default.
- W2065527144 title "Chronic Electrical Stimulation of the Left Ventrointermediate (Vim) Thalamic Nucleus for the Treatment of Pharmacotherapy-Resistant Parkinson's Disease: A Differential Impact on Access to Semantic and Episodic Memory?" @default.
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- W2065527144 doi "https://doi.org/10.1006/brcg.1998.1025" @default.
- W2065527144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9853093" @default.
- W2065527144 hasPublicationYear "1998" @default.
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