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• W2065536861 endingPage "1259" @default.
• W2065536861 startingPage "1252" @default.
• W2065536861 abstract "Some apparent characteristics of ganglion cell death in glaucomaGlaucoma is a progressive optic neuropathy with characteristic optic disc changes and associated visual field defects.1 2 The pattern and progression of visual field loss due to ganglion cell death varies between glaucoma patients suggesting that there is some variability in the magnitude of the insult responsible for the cell loss. Ganglion cell death with a spatial and temporal distribution typical of “glaucoma” can be experimentally induced in animals.3-5 One way to try and mimic glaucoma in experimental animals is to raise the intraocular pressure (IOP).3-6 It is clear from such studies that ganglion cells do not all die at the same time.4-8Furthermore, the rate of deterioration of ganglion cells is proportional to the magnitude of the insult.9 The reason for the initiation of ganglion cell death in glaucoma is unknown, but a number of explanatory theories have been proposed with the vasogenic theory perhaps the most widely accepted hypothesis.2 10-12 Raised IOP is not the sole factor responsible for glaucomatous retinal damage but an important one of a number that have been implicated (Fig 1).12-17 Only 10% of patients with increased IOP (⩾22 mm Hg) have glaucoma and between one third and one half of patients with glaucoma initially do not have elevated IOP.1 18 19 Furthermore, as many as one sixth of patients with glaucomatous damage do not appear to have elevated IOP.1 It is therefore clear that raised IOP is not synonymous with having glaucoma.1 20 21 Nevertheless, high IOP is arguably the most important risk factor (see Fig 1), and it is clearly associated with ganglion cell death in glaucoma patients.Figure 1 Possible causes of ganglion cell death in glaucoma. It is suggested that activation of …" @default.
• W2065536861 created "2016-06-24" @default.
• W2065536861 creator A5069352403 @default.
• W2065536861 date "2001-10-01" @default.
• W2065536861 modified "2023-09-28" @default.
• W2065536861 title "A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma" @default.
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