Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065543957> ?p ?o ?g. }
- W2065543957 endingPage "12849" @default.
- W2065543957 startingPage "12839" @default.
- W2065543957 abstract "The solute carrier family 11 member 1 (SLC11A1) gene is strictly regulated and exclusively expressed in myeloid lineage cells. However, little is known about the transcriptional regulation of the SLC11A1 gene during myeloid development. In this study, we used HL-60 cells as a model to investigate the regulatory elements/factors involved in the transactivation of the SLC11A1 gene during phorbol 12-myristate 13-acetate (PMA)-induced macrophage differentiation of HL-60 cells. Promoter deletion analysis showed that a 7-base AP-1-like element (TGACTCT) was critical for the responsiveness of the SLC11A1 promoter to PMA. Stimulation by PMA induced the binding of ATF-3 and the recruitment of two components of the SWI/SNF complex, BRG1 and β-actin, to this element in an ATF-3-dependent manner. RNAi-mediated depletion of ATF-3 or BRG1 markedly decreased SLC11A1 gene expression and its promoter activity induced by PMA. Luciferase reporter experiments demonstrated that ATF-3 cooperated with BRG1 and β-actin to activate the SLC11A1 promoter. Furthermore, we showed that PMA can induce the proximal (GT/AC)(n) repeat sequence to convert to the Z-DNA structure in the SLC11A1 gene promoter, and depletion of BRG1 resulted in a significant decrease of Z-DNA formation. Our results demonstrated that recruitment of the SWI/SNF complex initiated Z-DNA formation and subsequently helped to transactivate the SLC11A1 gene." @default.
- W2065543957 created "2016-06-24" @default.
- W2065543957 creator A5005324730 @default.
- W2065543957 creator A5006718015 @default.
- W2065543957 creator A5012177454 @default.
- W2065543957 creator A5071434659 @default.
- W2065543957 date "2011-04-01" @default.
- W2065543957 modified "2023-10-16" @default.
- W2065543957 title "Recruitment of SWI/SNF Complex Is Required for Transcriptional Activation of the SLC11A1 Gene during Macrophage Differentiation of HL-60 Cells" @default.
- W2065543957 cites W1547610032 @default.
- W2065543957 cites W1596604198 @default.
- W2065543957 cites W1600943063 @default.
- W2065543957 cites W1608648269 @default.
- W2065543957 cites W1642383742 @default.
- W2065543957 cites W1760824447 @default.
- W2065543957 cites W1863364305 @default.
- W2065543957 cites W1968472689 @default.
- W2065543957 cites W1970121621 @default.
- W2065543957 cites W1970219055 @default.
- W2065543957 cites W1974220331 @default.
- W2065543957 cites W1985358659 @default.
- W2065543957 cites W1986509587 @default.
- W2065543957 cites W1994203761 @default.
- W2065543957 cites W1994861290 @default.
- W2065543957 cites W1995249103 @default.
- W2065543957 cites W1995486061 @default.
- W2065543957 cites W1995668347 @default.
- W2065543957 cites W1997208014 @default.
- W2065543957 cites W2006818766 @default.
- W2065543957 cites W2007012438 @default.
- W2065543957 cites W2018941898 @default.
- W2065543957 cites W2021513717 @default.
- W2065543957 cites W2026368142 @default.
- W2065543957 cites W2040327353 @default.
- W2065543957 cites W2040730809 @default.
- W2065543957 cites W2048931739 @default.
- W2065543957 cites W2049266995 @default.
- W2065543957 cites W2051808699 @default.
- W2065543957 cites W2053443724 @default.
- W2065543957 cites W2053855583 @default.
- W2065543957 cites W2054244366 @default.
- W2065543957 cites W2057145009 @default.
- W2065543957 cites W2058556503 @default.
- W2065543957 cites W2059672758 @default.
- W2065543957 cites W2062983176 @default.
- W2065543957 cites W2063504630 @default.
- W2065543957 cites W2064567333 @default.
- W2065543957 cites W2064775719 @default.
- W2065543957 cites W2068065167 @default.
- W2065543957 cites W2075470041 @default.
- W2065543957 cites W2082959093 @default.
- W2065543957 cites W2084096180 @default.
- W2065543957 cites W2084995763 @default.
- W2065543957 cites W2085115632 @default.
- W2065543957 cites W2087535194 @default.
- W2065543957 cites W2088892416 @default.
- W2065543957 cites W2097848338 @default.
- W2065543957 cites W2098948988 @default.
- W2065543957 cites W2101940270 @default.
- W2065543957 cites W2107277218 @default.
- W2065543957 cites W2112716407 @default.
- W2065543957 cites W2125407920 @default.
- W2065543957 cites W2130873698 @default.
- W2065543957 cites W2133452708 @default.
- W2065543957 cites W2136122903 @default.
- W2065543957 cites W2138625851 @default.
- W2065543957 cites W2139477475 @default.
- W2065543957 cites W2143377660 @default.
- W2065543957 cites W2144860817 @default.
- W2065543957 cites W2145619015 @default.
- W2065543957 cites W2146035452 @default.
- W2065543957 cites W2146904676 @default.
- W2065543957 cites W2153833981 @default.
- W2065543957 cites W2156948371 @default.
- W2065543957 cites W2159952104 @default.
- W2065543957 cites W2161759739 @default.
- W2065543957 cites W2165585387 @default.
- W2065543957 cites W2167411243 @default.
- W2065543957 cites W2180006187 @default.
- W2065543957 cites W2417919723 @default.
- W2065543957 cites W35445691 @default.
- W2065543957 cites W4313151174 @default.
- W2065543957 doi "https://doi.org/10.1074/jbc.m110.185637" @default.
- W2065543957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3075631" @default.
- W2065543957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21300803" @default.
- W2065543957 hasPublicationYear "2011" @default.
- W2065543957 type Work @default.
- W2065543957 sameAs 2065543957 @default.
- W2065543957 citedByCount "30" @default.
- W2065543957 countsByYear W20655439572012 @default.
- W2065543957 countsByYear W20655439572013 @default.
- W2065543957 countsByYear W20655439572014 @default.
- W2065543957 countsByYear W20655439572015 @default.
- W2065543957 countsByYear W20655439572016 @default.
- W2065543957 countsByYear W20655439572017 @default.
- W2065543957 countsByYear W20655439572019 @default.
- W2065543957 countsByYear W20655439572021 @default.
- W2065543957 countsByYear W20655439572022 @default.