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• W2065544897 abstract "Activation of the mitogen-activated protein kinase (MAPK) pathway by the T-cell antigen receptor (TCR) in T cells involves a positive role for phosphatidylinositol 3-kinase (PI3K) activity. We recently reported that over-expression of the Syk protein tyrosine kinase in the Lck-negative JCaM1 cells enabled the TCR to induce a normal activiation of the Erk2 MAPK and enhanced transcription of a reporter gene driven by the nuclear factor of activated T cells and AP-1. Because this system allows us to analyse the targets for Syk in receptor-mediated signalling, we examined the role of PI3K in signalling events between the TCR-regulated Syk and the downstream activation of Erk2. We report that inhibition of PI3K by wortmannin or an inhibitory p85 construct, p85ΔiSH2, reduced the TCR-induced Syk-dependent activation of Erk2, as well as the appearance of phospho-Erk and phospho-Mek. At the same time, expression of Syk resulted in the activation-dependent phosphorylation of three proteins that bound to the src homology 2 (SH2) domains of PI3K p85. The strongest of these bands had an apparent molecular mass of 36–38 kDa on SDS gels, and it was quantitatively removed from the lysates by adsorption to a fusion protein containing the SH2 domain of Grb2. The appearance of this band was Syk dependent, and it was seen only upon triggering of the TCR complex. Thus, p36/38 was phosphorylated by Syk or a Syk-regulated kinase, and this protein may provide a link to the recruitment and activation of PI3K, as well as to the Ras-MAPK pathway, in TCR-triggered T cells." @default.
• W2065544897 created "2016-06-24" @default.
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• W2065544897 date "1998-06-01" @default.
• W2065544897 modified "2023-09-23" @default.
• W2065544897 title "Phosphorylation of the Grb2- and Phosphatidylinositol 3-Kinase p85–binding p36/38 by Syk in Lck-Negative T Cells" @default.
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• W2065544897 doi "https://doi.org/10.1016/s0898-6568(97)00139-3" @default.
• W2065544897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9720763" @default.
• W2065544897 hasPublicationYear "1998" @default.
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