FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065556910> ?p ?o ?g. }

• W2065556910 endingPage "491" @default.
• W2065556910 startingPage "485" @default.
• W2065556910 abstract "Amlodipine is a racemic mixture composed of S- and R-form and metabolized stereoselectively. Cytochrome P450 3A (CYP3A) including CYP3A5 are involved in the metabolism of amlodipine and it was reported that polymorphic CYP3A5 genotype modulates the plasma levels of amlodipine and thus affect its pharmacokinetics. This study was conducted to find whether stereoselective pharmacokinetics of amlodipine was affected by the polymorphic CYP3A5 genotype. Seventeen healthy subjects were genotyped for CYP3A5*3 variant. After a single dose of 10-mg amlodipine, enantiomers of amlodipine were analyzed using HPLC-MS/MS equipped with an AGP column. Amlodipine showed stereoselective pharmacokinetics. S-amlodipine exhibited higher plasma levels than R-amlodipine in both genotype groups. S-amlodipine showed 15% higher mean peak plasma concentrations (Cmax) in CYP3A5*1/*3 carriers (3.28 ng/ml) than CYP3A5*3/*3 carriers (2.85 ng/ml) (P = 0.194) and R-amlodipine also showed 21% higher Cmax in CYP3A5*1/*3 carriers (3.33 ng/ml) than CYP3A5*3/*3 carriers (2.75 ng/ml) (P = 0.114). CYP3A5*1/*3 carriers also have 23 and 12% higher mean area under the time versus concentration curve of R-amlodipine and S-amlodipine than CYP3A5*3/*3 carriers, respectively (for R-amlodipine, 147.1 ng*h/ml for CYP3A5*1/*3 carriers versus 121.8 ng*h/ml for CYP3A5*3/*3 carriers, P = 0.234; for S-amlodipine, 161.6 ng*h/ml for CYP3A5*1/*3 carriers vs. 144.2 ng*h/ml for CYP3A5*3/*3 carriers, P = 0.353). Other pharmacokinetic parameters also showed no significant difference between them. In conclusion, the present study showed that despite the evidence that amlodipine is stereoselectively metabolized, CYP3A5*3 genotype did not affect stereoselective disposition of amlodipine. It provides the evidence that CYP3A5*3genotype plays a minor role in the interindividual variability of stereoselective disposition of amlodipine in humans." @default.
• W2065556910 created "2016-06-24" @default.
• W2065556910 creator A5015481616 @default.
• W2065556910 creator A5050866517 @default.
• W2065556910 creator A5074147959 @default.
• W2065556910 date "2009-05-01" @default.
• W2065556910 modified "2023-09-27" @default.
• W2065556910 title "Effect ofcytochrome P450 3A5*3genotype on the stereoselective pharmacokinetics of amlodipine in healthy subjects" @default.
• W2065556910 cites W1496166354 @default.
• W2065556910 cites W1496427182 @default.
• W2065556910 cites W1526269646 @default.
• W2065556910 cites W1902589901 @default.
• W2065556910 cites W1966060815 @default.
• W2065556910 cites W1971684396 @default.
• W2065556910 cites W1982949658 @default.
• W2065556910 cites W1988611368 @default.
• W2065556910 cites W1990125568 @default.
• W2065556910 cites W1993368700 @default.
• W2065556910 cites W2005347374 @default.
• W2065556910 cites W2006998778 @default.
• W2065556910 cites W2010740511 @default.
• W2065556910 cites W2024913341 @default.
• W2065556910 cites W2028749073 @default.
• W2065556910 cites W2033725438 @default.
• W2065556910 cites W2035854710 @default.
• W2065556910 cites W2041248713 @default.
• W2065556910 cites W2051976688 @default.
• W2065556910 cites W2052406081 @default.
• W2065556910 cites W2075774432 @default.
• W2065556910 cites W2077886785 @default.
• W2065556910 cites W2084132265 @default.
• W2065556910 cites W2089078559 @default.
• W2065556910 cites W2090971729 @default.
• W2065556910 cites W2105902511 @default.
• W2065556910 cites W2151695776 @default.
• W2065556910 cites W2157049173 @default.
• W2065556910 cites W2160393958 @default.
• W2065556910 cites W2171823683 @default.
• W2065556910 cites W2358501499 @default.
• W2065556910 doi "https://doi.org/10.1002/chir.20588" @default.
• W2065556910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18752284" @default.
• W2065556910 hasPublicationYear "2009" @default.
• W2065556910 type Work @default.
• W2065556910 sameAs 2065556910 @default.
• W2065556910 citedByCount "11" @default.
• W2065556910 countsByYear W20655569102012 @default.
• W2065556910 countsByYear W20655569102014 @default.
• W2065556910 countsByYear W20655569102016 @default.
• W2065556910 countsByYear W20655569102017 @default.
• W2065556910 countsByYear W20655569102018 @default.
• W2065556910 countsByYear W20655569102019 @default.
• W2065556910 crossrefType "journal-article" @default.
• W2065556910 hasAuthorship W2065556910A5015481616 @default.
• W2065556910 hasAuthorship W2065556910A5050866517 @default.
• W2065556910 hasAuthorship W2065556910A5074147959 @default.
• W2065556910 hasConcept C104317684 @default.
• W2065556910 hasConcept C112705442 @default.
• W2065556910 hasConcept C11824378 @default.
• W2065556910 hasConcept C126322002 @default.
• W2065556910 hasConcept C135763542 @default.
• W2065556910 hasConcept C161790260 @default.
• W2065556910 hasConcept C181647583 @default.
• W2065556910 hasConcept C185592680 @default.
• W2065556910 hasConcept C22979827 @default.
• W2065556910 hasConcept C2779646130 @default.
• W2065556910 hasConcept C526171541 @default.
• W2065556910 hasConcept C55493867 @default.
• W2065556910 hasConcept C62231903 @default.
• W2065556910 hasConcept C71924100 @default.
• W2065556910 hasConcept C84393581 @default.
• W2065556910 hasConcept C92137452 @default.
• W2065556910 hasConcept C98274493 @default.
• W2065556910 hasConceptScore W2065556910C104317684 @default.
• W2065556910 hasConceptScore W2065556910C112705442 @default.
• W2065556910 hasConceptScore W2065556910C11824378 @default.
• W2065556910 hasConceptScore W2065556910C126322002 @default.
• W2065556910 hasConceptScore W2065556910C135763542 @default.
• W2065556910 hasConceptScore W2065556910C161790260 @default.
• W2065556910 hasConceptScore W2065556910C181647583 @default.
• W2065556910 hasConceptScore W2065556910C185592680 @default.
• W2065556910 hasConceptScore W2065556910C22979827 @default.
• W2065556910 hasConceptScore W2065556910C2779646130 @default.
• W2065556910 hasConceptScore W2065556910C526171541 @default.
• W2065556910 hasConceptScore W2065556910C55493867 @default.
• W2065556910 hasConceptScore W2065556910C62231903 @default.
• W2065556910 hasConceptScore W2065556910C71924100 @default.
• W2065556910 hasConceptScore W2065556910C84393581 @default.
• W2065556910 hasConceptScore W2065556910C92137452 @default.
• W2065556910 hasConceptScore W2065556910C98274493 @default.
• W2065556910 hasIssue "5" @default.
• W2065556910 hasLocation W20655569101 @default.
• W2065556910 hasLocation W20655569102 @default.
• W2065556910 hasOpenAccess W2065556910 @default.
• W2065556910 hasPrimaryLocation W20655569101 @default.
• W2065556910 hasRelatedWork W2059880023 @default.
• W2065556910 hasRelatedWork W2065556910 @default.
• W2065556910 hasRelatedWork W2132019166 @default.
• W2065556910 hasRelatedWork W2354200913 @default.

• next