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- W2065571115 endingPage "447" @default.
- W2065571115 startingPage "436" @default.
- W2065571115 abstract "Chromatin compaction has profound implications for the regulation of transcription, replication and DNA repair. Changes in nucleosome structure and stability — due to the incorporation of variant histones and post-translational modifications of histones — affect chromatin compaction. Chromatin structures are not nearly as uniform as previously assumed, which should be taken into account in the context of specific biological functions. The compaction of genomic DNA into chromatin has profound implications for the regulation of key processes such as transcription, replication and DNA repair. Nucleosomes, the repeating building blocks of chromatin, vary in the composition of their histone protein components. This is the result of the incorporation of variant histones and post-translational modifications of histone amino acid side chains. The resulting changes in nucleosome structure, stability and dynamics affect the compaction of nucleosomal arrays into higher-order structures. It is becoming clear that chromatin structures are not nearly as uniform and regular as previously assumed. This implies that chromatin structure must also be viewed in the context of specific biological functions." @default.
- W2065571115 created "2016-06-24" @default.
- W2065571115 creator A5001371883 @default.
- W2065571115 creator A5008949007 @default.
- W2065571115 creator A5031409746 @default.
- W2065571115 date "2012-06-22" @default.
- W2065571115 modified "2023-10-11" @default.
- W2065571115 title "New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?" @default.
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