FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065575458> ?p ?o ?g. }

• W2065575458 endingPage "2344" @default.
• W2065575458 startingPage "2331" @default.
• W2065575458 abstract "Autophagy is an evolutionarily conserved process that is essential for cellular homeostasis and organismal viability in eukaryotes. However, the extent of its functions in higher-order processes of organismal physiology and behavior is still unknown. Here, we report that autophagy is essential for the maintenance of balance in mice and that its deficiency leads to severe balance disorders. We generated mice deficient in autophagin-1 protease (Atg4b) and showed that they had substantial systemic reduction of autophagic activity. Autophagy reduction occurred through defective proteolytic processing of the autophagosome component LC3 and its paralogs, which compromised the rate of autophagosome maturation. Despite their viability, Atg4b-null mice showed unusual patterns of behavior that are common features of inner ear pathologies. Consistent with this, Atg4b-null mice showed defects in the development of otoconia, organic calcium carbonate crystals essential for sense of balance (equilibrioception). Furthermore, these abnormalities were exacerbated in Atg5–/– mice, which completely lack the ability to perform autophagy, confirming that autophagic activity is necessary for otoconial biogenesis. Autophagy deficiency also led to impaired secretion and assembly of otoconial core proteins, thus hampering otoconial development. Taken together, these results describe an essential role for autophagy in inner ear development and equilibrioception and open new possibilities for understanding and treating human balance disorders, which are of growing relevance among the elderly population." @default.
• W2065575458 created "2016-06-24" @default.
• W2065575458 creator A5012553729 @default.
• W2065575458 creator A5017486676 @default.
• W2065575458 creator A5041860416 @default.
• W2065575458 creator A5042293682 @default.
• W2065575458 creator A5046081835 @default.
• W2065575458 creator A5048423157 @default.
• W2065575458 creator A5048686565 @default.
• W2065575458 creator A5054865930 @default.
• W2065575458 creator A5055770461 @default.
• W2065575458 creator A5061472875 @default.
• W2065575458 creator A5087251720 @default.
• W2065575458 creator A5087974982 @default.
• W2065575458 date "2010-07-01" @default.
• W2065575458 modified "2023-10-18" @default.
• W2065575458 title "Autophagy is essential for mouse sense of balance" @default.
• W2065575458 cites W1543216066 @default.
• W2065575458 cites W1555054913 @default.
• W2065575458 cites W1844042040 @default.
• W2065575458 cites W1977767269 @default.
• W2065575458 cites W1988501412 @default.
• W2065575458 cites W1988874826 @default.
• W2065575458 cites W1992659717 @default.
• W2065575458 cites W1994823455 @default.
• W2065575458 cites W1995370028 @default.
• W2065575458 cites W1999836892 @default.
• W2065575458 cites W2001885448 @default.
• W2065575458 cites W2005997790 @default.
• W2065575458 cites W2006982649 @default.
• W2065575458 cites W2022812113 @default.
• W2065575458 cites W2026590190 @default.
• W2065575458 cites W2035087409 @default.
• W2065575458 cites W2035461331 @default.
• W2065575458 cites W2047589152 @default.
• W2065575458 cites W2049797765 @default.
• W2065575458 cites W2058231034 @default.
• W2065575458 cites W2061704745 @default.
• W2065575458 cites W2066800765 @default.
• W2065575458 cites W2068153705 @default.
• W2065575458 cites W2069938223 @default.
• W2065575458 cites W2070960209 @default.
• W2065575458 cites W2075880910 @default.
• W2065575458 cites W2087971388 @default.
• W2065575458 cites W2093530916 @default.
• W2065575458 cites W2095238101 @default.
• W2065575458 cites W2096853390 @default.
• W2065575458 cites W2097932424 @default.
• W2065575458 cites W2101259868 @default.
• W2065575458 cites W2102354517 @default.
• W2065575458 cites W2103046269 @default.
• W2065575458 cites W2109034822 @default.
• W2065575458 cites W2111892050 @default.
• W2065575458 cites W2115742671 @default.
• W2065575458 cites W2115886998 @default.
• W2065575458 cites W2119399459 @default.
• W2065575458 cites W2128537698 @default.
• W2065575458 cites W2129712803 @default.
• W2065575458 cites W2135574023 @default.
• W2065575458 cites W2135901758 @default.
• W2065575458 cites W2139425230 @default.
• W2065575458 cites W2146124002 @default.
• W2065575458 cites W2146887271 @default.
• W2065575458 cites W2153527056 @default.
• W2065575458 cites W2155452700 @default.
• W2065575458 cites W2161234475 @default.
• W2065575458 cites W2161615911 @default.
• W2065575458 cites W2166334343 @default.
• W2065575458 cites W2171662147 @default.
• W2065575458 cites W2792139654 @default.
• W2065575458 cites W4294216491 @default.
• W2065575458 doi "https://doi.org/10.1172/jci42601" @default.
• W2065575458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2898610" @default.
• W2065575458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20577052" @default.
• W2065575458 hasPublicationYear "2010" @default.
• W2065575458 type Work @default.
• W2065575458 sameAs 2065575458 @default.
• W2065575458 citedByCount "167" @default.
• W2065575458 countsByYear W20655754582012 @default.
• W2065575458 countsByYear W20655754582013 @default.
• W2065575458 countsByYear W20655754582014 @default.
• W2065575458 countsByYear W20655754582015 @default.
• W2065575458 countsByYear W20655754582016 @default.
• W2065575458 countsByYear W20655754582017 @default.
• W2065575458 countsByYear W20655754582018 @default.
• W2065575458 countsByYear W20655754582019 @default.
• W2065575458 countsByYear W20655754582020 @default.
• W2065575458 countsByYear W20655754582021 @default.
• W2065575458 countsByYear W20655754582022 @default.
• W2065575458 countsByYear W20655754582023 @default.
• W2065575458 crossrefType "journal-article" @default.
• W2065575458 hasAuthorship W2065575458A5012553729 @default.
• W2065575458 hasAuthorship W2065575458A5017486676 @default.
• W2065575458 hasAuthorship W2065575458A5041860416 @default.
• W2065575458 hasAuthorship W2065575458A5042293682 @default.
• W2065575458 hasAuthorship W2065575458A5046081835 @default.
• W2065575458 hasAuthorship W2065575458A5048423157 @default.
• W2065575458 hasAuthorship W2065575458A5048686565 @default.

• next