Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065576937> ?p ?o ?g. }
- W2065576937 abstract "Abstract This article reviews the challenges and future options in the treatment of ErbB2- positive metastatic breast cancer. It summarizes a presentation from a symposium that was held at the ECCO 14 congress in 2007. Despite great progress in the management of ErbB2-positive metastatic breast cancer, significant challenges remain in these patients. Many patients do not respond to trastuzumab-containing regimens or develop progressive disease within 1 year. Continuing trastuzumab in these patients has yet to show proven clinical benefit in prospective studies. Several targeted agents have been developed to overcome the limitations of current targeted therapy for ErbB2-positive breast cancer. One such agent, lapatinib, was recently approved in Europe in combination with capecitabine in patients previously treated with trastuzumab in the metastatic setting. The intracellular site of action of lapatinib may underlie substantial clinical benefit. Based on available data to date, novel ErbB2-targeted therapies may hold significant promise in the management of ErbB2-positive metastatic breast cancer." @default.
- W2065576937 created "2016-06-24" @default.
- W2065576937 creator A5016987068 @default.
- W2065576937 date "2008-03-01" @default.
- W2065576937 modified "2023-09-25" @default.
- W2065576937 title "Challenges in the treatment of ErbB2 (HER2)-positive breast cancer" @default.
- W2065576937 cites W1562350097 @default.
- W2065576937 cites W1836239578 @default.
- W2065576937 cites W1955007080 @default.
- W2065576937 cites W1973544946 @default.
- W2065576937 cites W1976098555 @default.
- W2065576937 cites W1982729445 @default.
- W2065576937 cites W1988936433 @default.
- W2065576937 cites W1995242599 @default.
- W2065576937 cites W1995275694 @default.
- W2065576937 cites W1999476814 @default.
- W2065576937 cites W1999513758 @default.
- W2065576937 cites W2006154529 @default.
- W2065576937 cites W2013073222 @default.
- W2065576937 cites W2013669698 @default.
- W2065576937 cites W2014457594 @default.
- W2065576937 cites W2021478257 @default.
- W2065576937 cites W2023681515 @default.
- W2065576937 cites W2027542837 @default.
- W2065576937 cites W2045134790 @default.
- W2065576937 cites W2045324973 @default.
- W2065576937 cites W2046507292 @default.
- W2065576937 cites W2066772614 @default.
- W2065576937 cites W2077498864 @default.
- W2065576937 cites W2095156669 @default.
- W2065576937 cites W2099022883 @default.
- W2065576937 cites W2107426197 @default.
- W2065576937 cites W2109402856 @default.
- W2065576937 cites W2112720107 @default.
- W2065576937 cites W2123299533 @default.
- W2065576937 cites W2124748060 @default.
- W2065576937 cites W2128307445 @default.
- W2065576937 cites W2133275607 @default.
- W2065576937 cites W2136704455 @default.
- W2065576937 cites W2140074016 @default.
- W2065576937 cites W2141393790 @default.
- W2065576937 cites W2145477245 @default.
- W2065576937 cites W2147761019 @default.
- W2065576937 cites W2148685331 @default.
- W2065576937 cites W2149456801 @default.
- W2065576937 cites W2149773268 @default.
- W2065576937 cites W2160703426 @default.
- W2065576937 cites W2161370545 @default.
- W2065576937 cites W2164194457 @default.
- W2065576937 cites W2168167705 @default.
- W2065576937 cites W2172265576 @default.
- W2065576937 cites W2184278156 @default.
- W2065576937 cites W2245378547 @default.
- W2065576937 cites W2249062935 @default.
- W2065576937 cites W2268388488 @default.
- W2065576937 cites W2318605753 @default.
- W2065576937 cites W2324278934 @default.
- W2065576937 doi "https://doi.org/10.1016/s1359-6349(08)70275-1" @default.
- W2065576937 hasPublicationYear "2008" @default.
- W2065576937 type Work @default.
- W2065576937 sameAs 2065576937 @default.
- W2065576937 citedByCount "1" @default.
- W2065576937 countsByYear W20655769372012 @default.
- W2065576937 crossrefType "journal-article" @default.
- W2065576937 hasAuthorship W2065576937A5016987068 @default.
- W2065576937 hasConcept C121608353 @default.
- W2065576937 hasConcept C126322002 @default.
- W2065576937 hasConcept C143998085 @default.
- W2065576937 hasConcept C177713679 @default.
- W2065576937 hasConcept C2775930923 @default.
- W2065576937 hasConcept C2777329042 @default.
- W2065576937 hasConcept C2777909004 @default.
- W2065576937 hasConcept C2779134260 @default.
- W2065576937 hasConcept C2779786085 @default.
- W2065576937 hasConcept C2781164504 @default.
- W2065576937 hasConcept C2781230642 @default.
- W2065576937 hasConcept C526805850 @default.
- W2065576937 hasConcept C530470458 @default.
- W2065576937 hasConcept C71924100 @default.
- W2065576937 hasConceptScore W2065576937C121608353 @default.
- W2065576937 hasConceptScore W2065576937C126322002 @default.
- W2065576937 hasConceptScore W2065576937C143998085 @default.
- W2065576937 hasConceptScore W2065576937C177713679 @default.
- W2065576937 hasConceptScore W2065576937C2775930923 @default.
- W2065576937 hasConceptScore W2065576937C2777329042 @default.
- W2065576937 hasConceptScore W2065576937C2777909004 @default.
- W2065576937 hasConceptScore W2065576937C2779134260 @default.
- W2065576937 hasConceptScore W2065576937C2779786085 @default.
- W2065576937 hasConceptScore W2065576937C2781164504 @default.
- W2065576937 hasConceptScore W2065576937C2781230642 @default.
- W2065576937 hasConceptScore W2065576937C526805850 @default.
- W2065576937 hasConceptScore W2065576937C530470458 @default.
- W2065576937 hasConceptScore W2065576937C71924100 @default.
- W2065576937 hasLocation W20655769371 @default.
- W2065576937 hasOpenAccess W2065576937 @default.
- W2065576937 hasPrimaryLocation W20655769371 @default.
- W2065576937 hasRelatedWork W101171352 @default.
- W2065576937 hasRelatedWork W188996788 @default.
- W2065576937 hasRelatedWork W1974701860 @default.
- W2065576937 hasRelatedWork W1999513758 @default.