FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065580458> ?p ?o ?g. }

• W2065580458 endingPage "e20826" @default.
• W2065580458 startingPage "e20826" @default.
• W2065580458 abstract "Gene expression patterns characterizing clinically-relevant molecular subgroups of glioblastoma are difficult to reproduce. We suspect a combination of biological and analytic factors confounds interpretation of glioblastoma expression data. We seek to clarify the nature and relative contributions of these factors, to focus additional investigations, and to improve the accuracy and consistency of translational glioblastoma analyses.We analyzed gene expression and clinical data for 340 glioblastomas in The Cancer Genome Atlas (TCGA). We developed a logic model to analyze potential sources of biological, technical, and analytic variability and used standard linear classifiers and linear dimensional reduction algorithms to investigate the nature and relative contributions of each factor.Commonly-described sources of classification error, including individual sample characteristics, batch effects, and analytic and technical noise make measurable but proportionally minor contributions to inconsistent molecular classification. Our analysis suggests that three, previously underappreciated factors may account for a larger fraction of classification errors: inherent non-linear/non-orthogonal relationships among the genes used in conjunction with classification algorithms that assume linearity; skewed data distributions assumed to be Gaussian; and biologic variability (noise) among tumors, of which we propose three types.Our analysis of the TCGA data demonstrates a contributory role for technical factors in molecular classification inconsistencies in glioblastoma but also suggests that biological variability, abnormal data distribution, and non-linear relationships among genes may be responsible for a proportionally larger component of classification error. These findings may have important implications for both glioblastoma research and for translational application of other large-volume biological databases." @default.
• W2065580458 created "2016-06-24" @default.
• W2065580458 creator A5016260607 @default.
• W2065580458 creator A5022741317 @default.
• W2065580458 creator A5084245470 @default.
• W2065580458 date "2011-07-28" @default.
• W2065580458 modified "2023-09-24" @default.
• W2065580458 title "Why Is There a Lack of Consensus on Molecular Subgroups of Glioblastoma? Understanding the Nature of Biological and Statistical Variability in Glioblastoma Expression Data" @default.
• W2065580458 cites W1509227233 @default.
• W2065580458 cites W1516095885 @default.
• W2065580458 cites W1527927437 @default.
• W2065580458 cites W1551305907 @default.
• W2065580458 cites W1603044149 @default.
• W2065580458 cites W1965434147 @default.
• W2065580458 cites W1986454483 @default.
• W2065580458 cites W1991707863 @default.
• W2065580458 cites W1992242907 @default.
• W2065580458 cites W1993034243 @default.
• W2065580458 cites W2004088708 @default.
• W2065580458 cites W2010637767 @default.
• W2065580458 cites W2019586039 @default.
• W2065580458 cites W2021239799 @default.
• W2065580458 cites W2025183726 @default.
• W2065580458 cites W2031043109 @default.
• W2065580458 cites W2031205682 @default.
• W2065580458 cites W2034710843 @default.
• W2065580458 cites W2038437697 @default.
• W2065580458 cites W2043789476 @default.
• W2065580458 cites W2047928920 @default.
• W2065580458 cites W2051262326 @default.
• W2065580458 cites W2055552685 @default.
• W2065580458 cites W2064214863 @default.
• W2065580458 cites W2096287682 @default.
• W2065580458 cites W2097917417 @default.
• W2065580458 cites W2102000647 @default.
• W2065580458 cites W2103017472 @default.
• W2065580458 cites W2105324766 @default.
• W2065580458 cites W2106323366 @default.
• W2065580458 cites W2106962250 @default.
• W2065580458 cites W2107665951 @default.
• W2065580458 cites W2109972881 @default.
• W2065580458 cites W2113942802 @default.
• W2065580458 cites W2118216623 @default.
• W2065580458 cites W2119000874 @default.
• W2065580458 cites W2120865735 @default.
• W2065580458 cites W2123060905 @default.
• W2065580458 cites W2126421206 @default.
• W2065580458 cites W2127938920 @default.
• W2065580458 cites W2128909276 @default.
• W2065580458 cites W2140301591 @default.
• W2065580458 cites W2140353888 @default.
• W2065580458 cites W2141055671 @default.
• W2065580458 cites W2142068617 @default.
• W2065580458 cites W2150926065 @default.
• W2065580458 cites W2154362705 @default.
• W2065580458 cites W2156857693 @default.
• W2065580458 cites W2158787958 @default.
• W2065580458 cites W2161289668 @default.
• W2065580458 cites W2162218188 @default.
• W2065580458 cites W2167015884 @default.
• W2065580458 cites W2167980479 @default.
• W2065580458 cites W2168546553 @default.
• W2065580458 cites W2170989872 @default.
• W2065580458 cites W2476954152 @default.
• W2065580458 cites W3101671285 @default.
• W2065580458 cites W4230792699 @default.
• W2065580458 cites W4294107304 @default.
• W2065580458 cites W4294216483 @default.
• W2065580458 cites W45534775 @default.
• W2065580458 cites W578899939 @default.
• W2065580458 doi "https://doi.org/10.1371/journal.pone.0020826" @default.
• W2065580458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3145641" @default.
• W2065580458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21829433" @default.
• W2065580458 hasPublicationYear "2011" @default.
• W2065580458 type Work @default.
• W2065580458 sameAs 2065580458 @default.
• W2065580458 citedByCount "17" @default.
• W2065580458 countsByYear W20655804582012 @default.
• W2065580458 countsByYear W20655804582013 @default.
• W2065580458 countsByYear W20655804582014 @default.
• W2065580458 countsByYear W20655804582015 @default.
• W2065580458 countsByYear W20655804582017 @default.
• W2065580458 crossrefType "journal-article" @default.
• W2065580458 hasAuthorship W2065580458A5016260607 @default.
• W2065580458 hasAuthorship W2065580458A5022741317 @default.
• W2065580458 hasAuthorship W2065580458A5084245470 @default.
• W2065580458 hasBestOaLocation W20655804581 @default.
• W2065580458 hasConcept C104317684 @default.
• W2065580458 hasConcept C105795698 @default.
• W2065580458 hasConcept C119857082 @default.
• W2065580458 hasConcept C124101348 @default.
• W2065580458 hasConcept C129848803 @default.
• W2065580458 hasConcept C150194340 @default.
• W2065580458 hasConcept C154945302 @default.
• W2065580458 hasConcept C163175372 @default.
• W2065580458 hasConcept C18431079 @default.
• W2065580458 hasConcept C201797286 @default.
• W2065580458 hasConcept C2776194525 @default.

• next