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- W2065592972 startingPage "261" @default.
- W2065592972 abstract "The effect of piperidine and D, L-pipecolic acid on a Ca2+ -dependent release of L-[3H] noradrenaline (L-[3H] NA), [3H] 5-hydroxytryptamine ([3H] 5-HT) and [14C] GABA from the rat brain slices preloaded of radioactive amines and acid were investigated. Piperidine 10-4 M did not affect high K+ -induced release of L-[3H] NA, [3H] 5-HT and [14C] GABA as well as spontaneous release of these amines and acid. On the other hand, D, L-pipecolic acid (10-4 M) significantly increased high K+ -induced release of [14C] GABA but not of L-[3H] NA or [3H] 5-HT. These results suggest that the hypnogenic and tranquilizing effect of piperidine is due to other mechanism than influence on NA, 5-HT and GABA at nerve terminals of central NA, 5-HT and GABA neurons, and that pipecolic acid possibly could potentiate the synaptic transmission of GABA in the central nervous system." @default.
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- W2065592972 date "1979-01-01" @default.
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- W2065592972 title "The effect of piperidine and pipecolic acid on high potassium-induced release of noradrenaline, serotonin and GABA from rat brain slices." @default.
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- W2065592972 doi "https://doi.org/10.1248/bpb1978.2.261" @default.
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