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• W2065593721 abstract "Background Few studies have addressed the association between the plasma concentration of disodium cromoglycate and its protective effects on patients with bronchial asthma. Objective We measured plasma concentrations of disodium cromoglycate for various asthmatic treatments in children and adolescents and estimated plasma concentrations and protective effects. Method Disodium cromoglycate as a 2-mg aerosol (n = 12), 4-mg aerosol (n = 5), or 20-mg nebulizer solution (n = 13) was inhaled by patients in remission. Results The plasma concentrations of disodium cromoglycate after 5 minutes of inhalation were 3.04 ± 2.72 ng/mL in the 2-mg aerosol group, 2.95 ± 0.86 ng/mL in the 4-mg aerosol group, and 7.72 ± 4.65 ng/mL in the nebulizer solution group. Subjects who used the nebulizer exhibited markedly higher plasma concentrations of disodium cromoglycate. There was a significant correlation between the concentration of disodium cromoglycate at 5 minutes and the protective effect determined by a ratio of the difference in the asthma score between baseline and treatment periods to the baseline asthma score. Conclusion When the plasma concentration of disodium cromoglycate is low, administration of larger aerosol dose or nebulization might be necessary. Few studies have addressed the association between the plasma concentration of disodium cromoglycate and its protective effects on patients with bronchial asthma. We measured plasma concentrations of disodium cromoglycate for various asthmatic treatments in children and adolescents and estimated plasma concentrations and protective effects. Disodium cromoglycate as a 2-mg aerosol (n = 12), 4-mg aerosol (n = 5), or 20-mg nebulizer solution (n = 13) was inhaled by patients in remission. The plasma concentrations of disodium cromoglycate after 5 minutes of inhalation were 3.04 ± 2.72 ng/mL in the 2-mg aerosol group, 2.95 ± 0.86 ng/mL in the 4-mg aerosol group, and 7.72 ± 4.65 ng/mL in the nebulizer solution group. Subjects who used the nebulizer exhibited markedly higher plasma concentrations of disodium cromoglycate. There was a significant correlation between the concentration of disodium cromoglycate at 5 minutes and the protective effect determined by a ratio of the difference in the asthma score between baseline and treatment periods to the baseline asthma score. When the plasma concentration of disodium cromoglycate is low, administration of larger aerosol dose or nebulization might be necessary." @default.
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• W2065593721 date "1999-12-01" @default.
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• W2065593721 title "Disodium cromoglycate use in children and adolescents with asthma: correlation between plasma concentrations and protective effects for various inhalation methods" @default.
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• W2065593721 doi "https://doi.org/10.1016/s1081-1206(10)62869-4" @default.
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