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- W2065603119 endingPage "e1000405" @default.
- W2065603119 startingPage "e1000405" @default.
- W2065603119 abstract "Infections by Neisseria meningitidis show duality between frequent asymptomatic carriage and occasional life-threatening disease. Bacterial and host factors involved in this balance are not fully understood. Cytopathic effects and cell damage may prelude to pathogenesis of isolates belonging to hyper-invasive lineages. We aimed to analyze cell–bacteria interactions using both pathogenic and carriage meningococcal isolates. Several pathogenic isolates of the ST-11 clonal complex and carriage isolates were used to infect human epithelial cells. Cytopathic effect was determined and apoptosis was scored using several methods (FITC-Annexin V staining followed by FACS analysis, caspase assays and DNA fragmentation). Only pathogenic isolates were able to induce apoptosis in human epithelial cells, mainly by lipooligosaccharide (endotoxin). Bioactive TNF-α is only detected when cells were infected by pathogenic isolates. At the opposite, carriage isolates seem to provoke shedding of the TNF-α receptor I (TNF-RI) from the surface that protect cells from apoptosis by chelating TNF-α. Ability to induce apoptosis and inflammation may represent major traits in the pathogenesis of N. meningitidis. However, our data strongly suggest that carriage isolates of meningococci reduce inflammatory response and apoptosis induction, resulting in the protection of their ecological niche at the human nasopharynx." @default.
- W2065603119 created "2016-06-24" @default.
- W2065603119 creator A5003642102 @default.
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- W2065603119 date "2009-05-01" @default.
- W2065603119 modified "2023-10-03" @default.
- W2065603119 title "Differential Modulation of TNF-α–Induced Apoptosis by Neisseria meningitidis" @default.
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- W2065603119 doi "https://doi.org/10.1371/journal.ppat.1000405" @default.
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- W2065603119 hasPublicationYear "2009" @default.
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