FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065604089> ?p ?o ?g. }

• W2065604089 abstract "Phosphatidylserine synthesis as measured by the incorporation of [(3)H]serine into phosphatidylserine (PtdSer) through the serine-base exchange enzyme system (serine-BEES) is markedly inhibited in Jurkat cells treated with caffeine. The caffeine-induced inhibition was compared to that observed in cells treated with either CD3 mAb or thapsigargin. While CD3- and thapsigargin-induced inhibition was related to the release of Ca(2+) from the endoplasmic reticulum (ER), a process that deprives the serine-BEES of its major cofactor, caffeine modified PtdSer synthesis in the absence of decreased Ca(2+) content of ER. Using Jurkat clones differing by the expression of cell surface markers or protein tyrosine kinases implicated in the CD3/TCR signal transmission pathway, we have shown that CD3 mAb-induced inhibition of PtdSer synthesis necessitates the expression of both the CD3/TCR and the protein tyrosine phosphatase CD45 at the cell surface as well as the presence of p56(lck) and ZAP-70 protein tyrosine kinases. By contrast, thapsigargin, a blocker of the Ca(2+)-ATPase of the ER, known for its Ca(2+) releasing properties, inhibited PtdSer synthesis in all the Jurkat clones tested, indicating that this compound bypasses the CD3/TCR-induced signals. Despite its lack of effect on Ca(2+) release from ER and on protein tyrosine phosphorylations, caffeine inhibited PtdSer synthesis in all the Jurkat clones. The use of several cAMP-inducing drugs and of others xanthine derivatives indicated that caffeine modify PtdSer synthesis either by a direct action on the serine-BEES or by a modification of the structure of the phospholipids used as substrate by the enzyme." @default.
• W2065604089 created "2016-06-24" @default.
• W2065604089 creator A5030162915 @default.
• W2065604089 creator A5044009414 @default.
• W2065604089 creator A5045950683 @default.
• W2065604089 date "1999-12-01" @default.
• W2065604089 modified "2023-09-27" @default.
• W2065604089 title "Regulation of Phosphatidylserine Synthesis in Jurkat T Cell Clones: Caffeine Bypasses CD3/TCR-Induced Protein Tyrosine Kinases and Calcium Signals" @default.
• W2065604089 cites W1483071957 @default.
• W2065604089 cites W1560835855 @default.
• W2065604089 cites W1590562493 @default.
• W2065604089 cites W1593810032 @default.
• W2065604089 cites W1656075393 @default.
• W2065604089 cites W1800193450 @default.
• W2065604089 cites W1968692205 @default.
• W2065604089 cites W1969921188 @default.
• W2065604089 cites W1977665325 @default.
• W2065604089 cites W1979555034 @default.
• W2065604089 cites W1980911959 @default.
• W2065604089 cites W1981070246 @default.
• W2065604089 cites W1983960385 @default.
• W2065604089 cites W1989885576 @default.
• W2065604089 cites W2008714169 @default.
• W2065604089 cites W2015084021 @default.
• W2065604089 cites W2023900185 @default.
• W2065604089 cites W2035920388 @default.
• W2065604089 cites W2039547987 @default.
• W2065604089 cites W2042248645 @default.
• W2065604089 cites W2043723591 @default.
• W2065604089 cites W2044151331 @default.
• W2065604089 cites W2047436637 @default.
• W2065604089 cites W2050419005 @default.
• W2065604089 cites W2060571726 @default.
• W2065604089 cites W2063601248 @default.
• W2065604089 cites W2071766003 @default.
• W2065604089 cites W2086524338 @default.
• W2065604089 cites W2094278677 @default.
• W2065604089 cites W2096793161 @default.
• W2065604089 cites W2107272556 @default.
• W2065604089 cites W2128270335 @default.
• W2065604089 cites W2151222579 @default.
• W2065604089 cites W2152311269 @default.
• W2065604089 cites W2153275719 @default.
• W2065604089 cites W2153423854 @default.
• W2065604089 cites W2157394873 @default.
• W2065604089 cites W215849618 @default.
• W2065604089 cites W2165161047 @default.
• W2065604089 cites W2410173452 @default.
• W2065604089 cites W96379975 @default.
• W2065604089 doi "https://doi.org/10.1006/bbrc.1999.1841" @default.
• W2065604089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10600531" @default.
• W2065604089 hasPublicationYear "1999" @default.
• W2065604089 type Work @default.
• W2065604089 sameAs 2065604089 @default.
• W2065604089 citedByCount "0" @default.
• W2065604089 crossrefType "journal-article" @default.
• W2065604089 hasAuthorship W2065604089A5030162915 @default.
• W2065604089 hasAuthorship W2065604089A5044009414 @default.
• W2065604089 hasAuthorship W2065604089A5045950683 @default.
• W2065604089 hasConcept C153911025 @default.
• W2065604089 hasConcept C158617107 @default.
• W2065604089 hasConcept C179464577 @default.
• W2065604089 hasConcept C19317047 @default.
• W2065604089 hasConcept C203014093 @default.
• W2065604089 hasConcept C2776090121 @default.
• W2065604089 hasConcept C2777146706 @default.
• W2065604089 hasConcept C2777553839 @default.
• W2065604089 hasConcept C2778918659 @default.
• W2065604089 hasConcept C2779637612 @default.
• W2065604089 hasConcept C41625074 @default.
• W2065604089 hasConcept C42362537 @default.
• W2065604089 hasConcept C55493867 @default.
• W2065604089 hasConcept C62478195 @default.
• W2065604089 hasConcept C85528070 @default.
• W2065604089 hasConcept C86803240 @default.
• W2065604089 hasConcept C8891405 @default.
• W2065604089 hasConcept C95444343 @default.
• W2065604089 hasConceptScore W2065604089C153911025 @default.
• W2065604089 hasConceptScore W2065604089C158617107 @default.
• W2065604089 hasConceptScore W2065604089C179464577 @default.
• W2065604089 hasConceptScore W2065604089C19317047 @default.
• W2065604089 hasConceptScore W2065604089C203014093 @default.
• W2065604089 hasConceptScore W2065604089C2776090121 @default.
• W2065604089 hasConceptScore W2065604089C2777146706 @default.
• W2065604089 hasConceptScore W2065604089C2777553839 @default.
• W2065604089 hasConceptScore W2065604089C2778918659 @default.
• W2065604089 hasConceptScore W2065604089C2779637612 @default.
• W2065604089 hasConceptScore W2065604089C41625074 @default.
• W2065604089 hasConceptScore W2065604089C42362537 @default.
• W2065604089 hasConceptScore W2065604089C55493867 @default.
• W2065604089 hasConceptScore W2065604089C62478195 @default.
• W2065604089 hasConceptScore W2065604089C85528070 @default.
• W2065604089 hasConceptScore W2065604089C86803240 @default.
• W2065604089 hasConceptScore W2065604089C8891405 @default.
• W2065604089 hasConceptScore W2065604089C95444343 @default.
• W2065604089 hasLocation W20656040891 @default.
• W2065604089 hasLocation W20656040892 @default.
• W2065604089 hasOpenAccess W2065604089 @default.
• W2065604089 hasPrimaryLocation W20656040891 @default.
• W2065604089 hasRelatedWork W1560506719 @default.

• next