Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065606989> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W2065606989 endingPage "256" @default.
- W2065606989 startingPage "256" @default.
- W2065606989 abstract "Bicarbonate Administration Is Potentially Harmful in Patients with Moderate Acidosis In Response: I would like to thank Dr. Soto for showing such a detailed interest in our recent study (1). Our study attempted to determine if any differences in outcome could be detected in patients undergoing aortic aneurysm repair when lactated Ringer’s solution or normal saline solution was used as the primary crystalloid solution. One of the outcome end points assessed was the amount of sodium bicarbonate used to treat acidosis. Dr. Soto correctly assumes that the choice of a base deficit of −5 mEq/L as a trigger for bicarbonate treatment was chosen as a compromise end point; however, the compromise was not to satisfy our IRB but rather the perspective of our surgeons and anesthesiologists who feel that tight maintenance of acid-base and electrolyte homeostasis is important during aortic cross-clamping. It is difficult to argue with their perspective because there is conflicting data regarding the intracellular acidosis to which Dr. Soto refers. The title of a recent editorial in Critical Care Medicine, “Sodium bicarbonate and intracellular acidosis: Myth or reality?”(2) alludes to this debate. In any study protocol, one needs to establish a trigger for therapeutic intervention, and that is what we did in our study. We agree with Dr. Soto that in many situations, we would not treat an acidosis with a base deficit of −5 mmol/L. In the studied clinical scenario, aortic aneurysm repair where an aortic cross-clamp is applied for a prolonged period of time, a base deficit of −5 mmol/L is only one point on a downward trend. Thus, we felt that it represented a legitimate therapeutic treatment point. We agree that the potential value of therapy in the treatment of severe acidemia remains an important issue, but further studies are required to fully delineate the scope and efficacy of bicarbonate treatment. Jonathan H. Waters, MD Alexandru Gottlieb, MD Juraj Sprung, MD" @default.
- W2065606989 created "2016-06-24" @default.
- W2065606989 creator A5002311921 @default.
- W2065606989 creator A5005627457 @default.
- W2065606989 creator A5071799465 @default.
- W2065606989 date "2002-07-01" @default.
- W2065606989 modified "2023-09-25" @default.
- W2065606989 title "Bicarbonate Administration Is Potentially Harmful in Patients with Moderate Acidosis" @default.
- W2065606989 cites W1970127420 @default.
- W2065606989 cites W2117005662 @default.
- W2065606989 doi "https://doi.org/10.1097/00000539-200207000-00063" @default.
- W2065606989 hasPublicationYear "2002" @default.
- W2065606989 type Work @default.
- W2065606989 sameAs 2065606989 @default.
- W2065606989 citedByCount "1" @default.
- W2065606989 crossrefType "journal-article" @default.
- W2065606989 hasAuthorship W2065606989A5002311921 @default.
- W2065606989 hasAuthorship W2065606989A5005627457 @default.
- W2065606989 hasAuthorship W2065606989A5071799465 @default.
- W2065606989 hasConcept C126322002 @default.
- W2065606989 hasConcept C147789679 @default.
- W2065606989 hasConcept C177713679 @default.
- W2065606989 hasConcept C185592680 @default.
- W2065606989 hasConcept C2776420369 @default.
- W2065606989 hasConcept C2778553927 @default.
- W2065606989 hasConcept C2779246250 @default.
- W2065606989 hasConcept C2781112554 @default.
- W2065606989 hasConcept C42219234 @default.
- W2065606989 hasConcept C71924100 @default.
- W2065606989 hasConceptScore W2065606989C126322002 @default.
- W2065606989 hasConceptScore W2065606989C147789679 @default.
- W2065606989 hasConceptScore W2065606989C177713679 @default.
- W2065606989 hasConceptScore W2065606989C185592680 @default.
- W2065606989 hasConceptScore W2065606989C2776420369 @default.
- W2065606989 hasConceptScore W2065606989C2778553927 @default.
- W2065606989 hasConceptScore W2065606989C2779246250 @default.
- W2065606989 hasConceptScore W2065606989C2781112554 @default.
- W2065606989 hasConceptScore W2065606989C42219234 @default.
- W2065606989 hasConceptScore W2065606989C71924100 @default.
- W2065606989 hasIssue "1" @default.
- W2065606989 hasLocation W20656069891 @default.
- W2065606989 hasOpenAccess W2065606989 @default.
- W2065606989 hasPrimaryLocation W20656069891 @default.
- W2065606989 hasRelatedWork W1531824061 @default.
- W2065606989 hasRelatedWork W1964025576 @default.
- W2065606989 hasRelatedWork W1969358452 @default.
- W2065606989 hasRelatedWork W2016548969 @default.
- W2065606989 hasRelatedWork W2044302200 @default.
- W2065606989 hasRelatedWork W2048800179 @default.
- W2065606989 hasRelatedWork W2073074692 @default.
- W2065606989 hasRelatedWork W2330770260 @default.
- W2065606989 hasRelatedWork W2406939132 @default.
- W2065606989 hasRelatedWork W2742251895 @default.
- W2065606989 hasVolume "95" @default.
- W2065606989 isParatext "false" @default.
- W2065606989 isRetracted "false" @default.
- W2065606989 magId "2065606989" @default.
- W2065606989 workType "article" @default.