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• W2065607546 abstract "Potent small molecule antagonists of the urotensin receptor are described. These inhibitors were derived via systematically deconstructing a literature inhibitor to understand the basic pharmacophore and key molecular features required to inhibit the protein receptor. The series of benzylamine and benzylsulfone antagonists herein reported display a combination of nanomolar molecular and cellular potency as well as acceptable in vitro permeability and metabolic stability." @default.
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• W2065607546 date "2013-04-01" @default.
• W2065607546 modified "2023-09-23" @default.
• W2065607546 title "Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists" @default.
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• W2065607546 doi "https://doi.org/10.1016/j.bmcl.2013.01.105" @default.
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