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- W2065609013 endingPage "2480" @default.
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- W2065609013 abstract "The catalytic enantioselective and divergent total syntheses of Aspidosperma alkaloids (+)-10-oxocylindrocarpidine 7, (+)-cylindrocarpidine 1, (−)-N-acetylcylindrocarpinol 6, and (+)-aspidospermine 8 have been accomplished in 11 steps from a common precursor (15) on the basis of a highly concise route. The route features three metal-catalyzed reactions, including the key Pd-catalyzed decarboxylative asymmetric allylation of carbazolones developed in our laboratory. Our syntheses, using a combination of C–H activation, enantioselective catalysis, and collective synthesis, represent the first total synthesis of 10-oxocylindrocarpidine and the first asymmetric total synthesis of cylindrocarpidine and N-acetylcylindrocarpinol." @default.
- W2065609013 created "2016-06-24" @default.
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- W2065609013 date "2014-02-28" @default.
- W2065609013 modified "2023-10-03" @default.
- W2065609013 title "Catalytic Enantioselective and Divergent Total Synthesis of (+)-10-Oxocylindrocarpidine, (+)-Cylindrocarpidine, (−)-<i>N</i>-Acetylcylindrocarpinol, and (+)-Aspidospermine" @default.
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- W2065609013 doi "https://doi.org/10.1021/jo402741g" @default.
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