FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065609541> ?p ?o ?g. }

• W2065609541 endingPage "18091" @default.
• W2065609541 startingPage "18085" @default.
• W2065609541 abstract "Sterile 20 (STE20) protein kinases, which include germinal center kinases and p21-activated protein kinases, are known to activate mitogen-activated protein kinase pathways (c-Jun NH2-terminal kinase, p38, or extracellular signal-regulated kinase), leading to changes in gene transcription. Some STE20s can also regulate the cytoskeleton, and we have shown that the germinal center kinase-like kinase prostate-derived STE20-like kinase (PSK) affects actin cytoskeletal organization. Here, we demonstrate that PSK colocalizes with microtubules; and that this localization is disrupted by the microtubule depolymerizing agent nocodazole. The association of PSK with microtubules results in the production of stabilized perinuclear microtubule cables that are nocodazole-resistant and contain increased levels of acetylated α-tubulin. Kinase-defective PSK (K57A) or the C terminus of PSK (amino acids 745–1235) lacking the kinase domain are sufficient for microtubule binding and stabilization, demonstrating that the catalytic activity of the protein is not required. The localization of PSK to microtubules occurs via its C terminus, and PSK binds and phosphorylates α- and β-tubulin in vitro. The N terminus of PSK (1–940) is unable to bind or stabilize microtubules, demonstrating that PSK must associate with microtubules for their reorganization to occur. These results demonstrate that PSK interacts with microtubules and affects their organization and stability independently of PSK kinase activity." @default.
• W2065609541 created "2016-06-24" @default.
• W2065609541 creator A5010230447 @default.
• W2065609541 creator A5052293314 @default.
• W2065609541 creator A5063297467 @default.
• W2065609541 creator A5073906482 @default.
• W2065609541 creator A5083593260 @default.
• W2065609541 date "2003-05-01" @default.
• W2065609541 modified "2023-10-02" @default.
• W2065609541 title "The Prostate-derived Sterile 20-like Kinase (PSK) Regulates Microtubule Organization and Stability" @default.
• W2065609541 cites W1490646520 @default.
• W2065609541 cites W1501075116 @default.
• W2065609541 cites W1511026292 @default.
• W2065609541 cites W1523601423 @default.
• W2065609541 cites W1561407320 @default.
• W2065609541 cites W1968606500 @default.
• W2065609541 cites W1978218402 @default.
• W2065609541 cites W1986349419 @default.
• W2065609541 cites W1986571317 @default.
• W2065609541 cites W1991990844 @default.
• W2065609541 cites W1997705463 @default.
• W2065609541 cites W2001669607 @default.
• W2065609541 cites W2002241817 @default.
• W2065609541 cites W2004375684 @default.
• W2065609541 cites W2006466204 @default.
• W2065609541 cites W2009575166 @default.
• W2065609541 cites W2010287708 @default.
• W2065609541 cites W2017328399 @default.
• W2065609541 cites W2019235377 @default.
• W2065609541 cites W2034180982 @default.
• W2065609541 cites W2037610353 @default.
• W2065609541 cites W203854621 @default.
• W2065609541 cites W2047211238 @default.
• W2065609541 cites W2047270293 @default.
• W2065609541 cites W2054813108 @default.
• W2065609541 cites W2055557491 @default.
• W2065609541 cites W2066712737 @default.
• W2065609541 cites W2095152052 @default.
• W2065609541 cites W2096910934 @default.
• W2065609541 cites W2101447126 @default.
• W2065609541 cites W2103957479 @default.
• W2065609541 cites W2107941234 @default.
• W2065609541 cites W2112289577 @default.
• W2065609541 cites W2121810961 @default.
• W2065609541 cites W2133181593 @default.
• W2065609541 cites W2144240811 @default.
• W2065609541 cites W2151233370 @default.
• W2065609541 cites W2153284157 @default.
• W2065609541 cites W2154142433 @default.
• W2065609541 cites W2156564701 @default.
• W2065609541 cites W2158584175 @default.
• W2065609541 cites W2163591703 @default.
• W2065609541 cites W2167096785 @default.
• W2065609541 doi "https://doi.org/10.1074/jbc.m213064200" @default.
• W2065609541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12639963" @default.
• W2065609541 hasPublicationYear "2003" @default.
• W2065609541 type Work @default.
• W2065609541 sameAs 2065609541 @default.
• W2065609541 citedByCount "50" @default.
• W2065609541 countsByYear W20656095412012 @default.
• W2065609541 countsByYear W20656095412013 @default.
• W2065609541 countsByYear W20656095412014 @default.
• W2065609541 countsByYear W20656095412017 @default.
• W2065609541 countsByYear W20656095412018 @default.
• W2065609541 countsByYear W20656095412020 @default.
• W2065609541 countsByYear W20656095412021 @default.
• W2065609541 countsByYear W20656095412022 @default.
• W2065609541 countsByYear W20656095412023 @default.
• W2065609541 crossrefType "journal-article" @default.
• W2065609541 hasAuthorship W2065609541A5010230447 @default.
• W2065609541 hasAuthorship W2065609541A5052293314 @default.
• W2065609541 hasAuthorship W2065609541A5063297467 @default.
• W2065609541 hasAuthorship W2065609541A5073906482 @default.
• W2065609541 hasAuthorship W2065609541A5083593260 @default.
• W2065609541 hasBestOaLocation W20656095411 @default.
• W2065609541 hasConcept C142669718 @default.
• W2065609541 hasConcept C1491633281 @default.
• W2065609541 hasConcept C159479382 @default.
• W2065609541 hasConcept C184235292 @default.
• W2065609541 hasConcept C20418707 @default.
• W2065609541 hasConcept C2779363559 @default.
• W2065609541 hasConcept C55493867 @default.
• W2065609541 hasConcept C82495950 @default.
• W2065609541 hasConcept C84425145 @default.
• W2065609541 hasConcept C86803240 @default.
• W2065609541 hasConcept C95444343 @default.
• W2065609541 hasConcept C97029542 @default.
• W2065609541 hasConceptScore W2065609541C142669718 @default.
• W2065609541 hasConceptScore W2065609541C1491633281 @default.
• W2065609541 hasConceptScore W2065609541C159479382 @default.
• W2065609541 hasConceptScore W2065609541C184235292 @default.
• W2065609541 hasConceptScore W2065609541C20418707 @default.
• W2065609541 hasConceptScore W2065609541C2779363559 @default.
• W2065609541 hasConceptScore W2065609541C55493867 @default.
• W2065609541 hasConceptScore W2065609541C82495950 @default.
• W2065609541 hasConceptScore W2065609541C84425145 @default.
• W2065609541 hasConceptScore W2065609541C86803240 @default.
• W2065609541 hasConceptScore W2065609541C95444343 @default.

• next