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• W2065617816 abstract "This study used behavioural and in vivo electrophysiological paradigms to examine the effects of systemic and spinal administration of a bradykinin B1 receptor antagonist, compound X, on acute nociceptive responses in the rat. In behavioural experiments, compound X significantly increased the latency to withdraw the hindpaw from a radiant heat source after both intravenous and intrathecal administration, without affecting motor performance on the rotarod. In electrophysiological experiments, both intravenous and direct spinal administration of compound X attenuated the responses of single dorsal horn neurones to noxious thermal stimulation of the hindpaw. These data show that the antinociceptive effects of a bradykinin B1 receptor antagonist are mediated, at least in part, at the level of the spinal cord and suggest a role for spinal bradykinin B1 receptors in acute nociception." @default.
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• W2065617816 date "2005-12-01" @default.
• W2065617816 modified "2023-10-18" @default.
• W2065617816 title "Inhibition of acute nociceptive responses in rat spinal cord by a bradykinin B1 receptor antagonist" @default.
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• W2065617816 doi "https://doi.org/10.1016/j.ejphar.2005.06.057" @default.
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