Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065620512> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2065620512 endingPage "903" @default.
- W2065620512 startingPage "903" @default.
- W2065620512 abstract "Objective: To determine if low-dose involved field radiation after complete remission induction with chemotherapy is effective in preventing relapse and improving survival in patients with stage III or IV Hodgkin disease. Design: A randomized, controlled trial with a median follow-up time of 8.1 years. Setting: A Southwest Oncology Group multi-institutional study. Patients were entered from university- and community-based practices. Patients: 278 adults with clinical or pathologic stage III or IV Hodgkin disease, who achieved complete responses after 6 cycles of MOP-BAP (nitrogen mustard, vincristine, prednisone, bleomycin, doxorubicin, and procarbazine) and who agreed to be randomly assigned to either radiation or no further treatment. Intervention: Patients were assigned to either no further treatment or low-dose radiation to all initially involved sites (radiation dose, 2000 cGy to lymph node areas and 1000 to 1500 cGy to other involved organ sites). Measurements: Differences in remission duration, relapse-free survival, and survival. Results: Remission duration, relapse-free survival, and overall survival were similar for the two groups (P = 0.09, P > 0.2, and P = 0.14, respectively). Factors that predicted shorter remission duration in a multivariate analysis were nodular sclerosis histology, bulky disease, and receipt of less than 85% of planned chemotherapy. Low-dose radiation improved remission duration in the subgroups of patients with nodular sclerosis and bulky disease. For the 169 patients with nodular sclerosis, the 5-year remission-duration estimate was 82% for the low-dose radiation group and 60% for the no further treatment group (P = 0.002). For all patients with bulky disease, the 5-year remission-duration estimate was 75% for the low-dose radiation group and 57% for the no further treatment group (P = 0.05). No difference in overall survival was noted between low-dose radiation and no further treatment in all patients or major subgroups. The 5-year survival was 86% for all patients who had a complete response as well as for patients in the nodular sclerosis subgroup. Conclusions: Low-dose involved field radiation after MOP-BAP chemotherapy in patients with stage III or IV Hodgkin disease did not prolong remission duration or overall survival in randomized patients. However, remission duration was prolonged in several subgroups of patients, most prominently in those with nodular sclerosis histology." @default.
- W2065620512 created "2016-06-24" @default.
- W2065620512 creator A5059485304 @default.
- W2065620512 date "1994-06-01" @default.
- W2065620512 modified "2023-10-18" @default.
- W2065620512 title "Low-Dose Involved Field Radiation after Chemotherapy in Advanced Hodgkin Disease: A Southwest Oncology Group Randomized Study" @default.
- W2065620512 doi "https://doi.org/10.7326/0003-4819-120-11-199406010-00002" @default.
- W2065620512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8172436" @default.
- W2065620512 hasPublicationYear "1994" @default.
- W2065620512 type Work @default.
- W2065620512 sameAs 2065620512 @default.
- W2065620512 citedByCount "171" @default.
- W2065620512 countsByYear W20656205122012 @default.
- W2065620512 countsByYear W20656205122013 @default.
- W2065620512 countsByYear W20656205122014 @default.
- W2065620512 countsByYear W20656205122015 @default.
- W2065620512 countsByYear W20656205122016 @default.
- W2065620512 countsByYear W20656205122017 @default.
- W2065620512 countsByYear W20656205122018 @default.
- W2065620512 countsByYear W20656205122019 @default.
- W2065620512 countsByYear W20656205122020 @default.
- W2065620512 countsByYear W20656205122021 @default.
- W2065620512 countsByYear W20656205122023 @default.
- W2065620512 crossrefType "journal-article" @default.
- W2065620512 hasAuthorship W2065620512A5059485304 @default.
- W2065620512 hasConcept C126322002 @default.
- W2065620512 hasConcept C141071460 @default.
- W2065620512 hasConcept C143998085 @default.
- W2065620512 hasConcept C168563851 @default.
- W2065620512 hasConcept C2776694085 @default.
- W2065620512 hasConcept C2776755627 @default.
- W2065620512 hasConcept C2778720950 @default.
- W2065620512 hasConcept C2779112685 @default.
- W2065620512 hasConcept C2779338263 @default.
- W2065620512 hasConcept C2779429289 @default.
- W2065620512 hasConcept C2780430958 @default.
- W2065620512 hasConcept C2992779791 @default.
- W2065620512 hasConcept C509974204 @default.
- W2065620512 hasConcept C71924100 @default.
- W2065620512 hasConcept C90924648 @default.
- W2065620512 hasConceptScore W2065620512C126322002 @default.
- W2065620512 hasConceptScore W2065620512C141071460 @default.
- W2065620512 hasConceptScore W2065620512C143998085 @default.
- W2065620512 hasConceptScore W2065620512C168563851 @default.
- W2065620512 hasConceptScore W2065620512C2776694085 @default.
- W2065620512 hasConceptScore W2065620512C2776755627 @default.
- W2065620512 hasConceptScore W2065620512C2778720950 @default.
- W2065620512 hasConceptScore W2065620512C2779112685 @default.
- W2065620512 hasConceptScore W2065620512C2779338263 @default.
- W2065620512 hasConceptScore W2065620512C2779429289 @default.
- W2065620512 hasConceptScore W2065620512C2780430958 @default.
- W2065620512 hasConceptScore W2065620512C2992779791 @default.
- W2065620512 hasConceptScore W2065620512C509974204 @default.
- W2065620512 hasConceptScore W2065620512C71924100 @default.
- W2065620512 hasConceptScore W2065620512C90924648 @default.
- W2065620512 hasIssue "11" @default.
- W2065620512 hasLocation W20656205121 @default.
- W2065620512 hasLocation W20656205122 @default.
- W2065620512 hasOpenAccess W2065620512 @default.
- W2065620512 hasPrimaryLocation W20656205121 @default.
- W2065620512 hasRelatedWork W1986487042 @default.
- W2065620512 hasRelatedWork W2004932524 @default.
- W2065620512 hasRelatedWork W2009209195 @default.
- W2065620512 hasRelatedWork W2044362603 @default.
- W2065620512 hasRelatedWork W2047206303 @default.
- W2065620512 hasRelatedWork W2138201596 @default.
- W2065620512 hasRelatedWork W2143831053 @default.
- W2065620512 hasRelatedWork W2403869922 @default.
- W2065620512 hasRelatedWork W2916489774 @default.
- W2065620512 hasRelatedWork W4247335802 @default.
- W2065620512 hasVolume "120" @default.
- W2065620512 isParatext "false" @default.
- W2065620512 isRetracted "false" @default.
- W2065620512 magId "2065620512" @default.
- W2065620512 workType "article" @default.