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- W2065623760 abstract "Acute promyelocytic leukaemia (APL) with t(11;17)/PLZF-RARα responds poorly to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3), in contrast to APL with t(15;17)/PML-RARα. Molecular studies have shown that histone deacetylase (HDAC) recruited by PLZF-RARα is associated with the ATRA resistance. Here, we analysed in vitro the differentiation of APL cells with t(11;17) using ATRA, As203, granulocyte colony-stimulating factor (G-CSF), HDAC inhibitor trichostatin A (TSA), or combinations of these. Although 1 μm ATRA, which stimulated the differentiation of APL cells with t(15;17), was insufficient to induce differentiation, 3 μm ATRA induced terminal differentiation into granulocytes. As203 alone or in combination with ATRA induced neither differentiation nor apoptosis. However, the combination of TSA and 1 μm ATRA had a potent differentiating effect, although TSA alone had little effect. The combination of 1 μm ATRA and G-CSF did not induce differentiation. These results indicate that APL cells with t(11;17) need a higher concentration of ATRA than those with t(15;17) to differentiate and suggest that HDAC inhibitor is a promising differentiation enhancer in APL with t(11;17)." @default.
- W2065623760 created "2016-06-24" @default.
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- W2065623760 date "2000-03-29" @default.
- W2065623760 modified "2023-09-24" @default.
- W2065623760 title "Histone deacetylase inhibitor but not arsenic trioxide differentiates acute promyelocytic leukaemia cells with t(11;17) in combination with all-<i>trans</i>retinoic acid" @default.
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- W2065623760 doi "https://doi.org/10.1046/j.1365-2141.2000.01933.x" @default.
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