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- W2065624006 abstract "Abstract N ‐methyl‐ d ‐aspartate receptors (NMDARs) are known to play critical roles in the development of the nervous system, and their expression is regulated in an activity‐dependent fashion during development. However, the regulation of NMDAR expression after circuit formation is less well understood. To examine this, we performed patch‐clamp recordings from chick cerebral neurons in an activity‐controlled culture. Analysis of NMDAR channels from neurons before synapse formation showed that there are two components in channel open kinetics. The major slow component is clearly blocked by ifenprodil, a specific inhibitor of NR2B‐containing NMDARs. In contrast, slow component of NMDAR channel opening from neurons after synapse formation became minor and ifenprodil had little effect on the NMDAR channel openings. Furthermore, this change is reversibly regulated by neuronal activity, in that suppression induces the re‐expression of NR2B‐containing NMDARs, even after circuit formation." @default.
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- W2065624006 date "2004-02-06" @default.
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- W2065624006 title "Re‐expression of NR2B‐containing NMDA receptors in vitro by suppression of neuronal activity" @default.
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- W2065624006 doi "https://doi.org/10.1016/j.ijdevneu.2003.12.007" @default.
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