FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065626701> ?p ?o ?g. }

• W2065626701 abstract "For a long time, Enterococcus faecium was considered a harmless commensal of the mammalian gastrointestinal (GI) tract and was used as a probiotic in fermented foods. In recent decades, E. faecium has been recognised as an opportunistic pathogen that causes diseases such as neonatal meningitis, urinary tract infections, bacteremia, bacterial endocarditis and diverticulitis. E. faecium could be taken into space with astronauts and exposed to the space environment. Thus, it is necessary to observe the phenotypic and molecular changes of E. faecium after spaceflight. An E. faecium mutant with biochemical features that are different from those of the wild-type strain was obtained from subculture after flight on the SHENZHOU-8 spacecraft. To understand the underlying mechanism causing these changes, the whole genomes of both the mutant and the WT strains were sequenced using Illumina technology. The genomic comparison revealed that dprA, a recombination-mediator gene, and arpU, a gene associated with cell wall growth, were mutated. Comparative transcriptomic and proteomic analyses showed that differentially expressed genes or proteins were involved with replication, recombination, repair, cell wall biogenesis, glycometabolism, lipid metabolism, amino acid metabolism, predicted general function and energy production/conversion. This study analysed the comprehensive genomic, transcriptomic and proteomic changes of an E. faecium mutant from subcultures that were loaded on the SHENZHOU-8 spacecraft. The implications of these gene mutations and expression changes and their underlying mechanisms should be investigated in the future. We hope that the current exploration of multiple “-omics” analyses of this E. faecium mutant will provide clues for future studies on this opportunistic pathogen." @default.
• W2065626701 created "2016-06-24" @default.
• W2065626701 creator A5012278873 @default.
• W2065626701 creator A5014578752 @default.
• W2065626701 creator A5018735035 @default.
• W2065626701 creator A5023714026 @default.
• W2065626701 creator A5036837044 @default.
• W2065626701 creator A5045824135 @default.
• W2065626701 creator A5048718004 @default.
• W2065626701 creator A5054907664 @default.
• W2065626701 creator A5057739867 @default.
• W2065626701 creator A5059772660 @default.
• W2065626701 creator A5062907871 @default.
• W2065626701 creator A5067107917 @default.
• W2065626701 creator A5070568001 @default.
• W2065626701 creator A5077894708 @default.
• W2065626701 creator A5090159939 @default.
• W2065626701 date "2013-12-01" @default.
• W2065626701 modified "2023-10-12" @default.
• W2065626701 title "A multi-omic analysis of an Enterococcus faecium mutant reveals specific genetic mutations and dramatic changes in mRNA and protein expression" @default.
• W2065626701 cites W1506603736 @default.
• W2065626701 cites W1965202162 @default.
• W2065626701 cites W1981509058 @default.
• W2065626701 cites W1990853496 @default.
• W2065626701 cites W2003144438 @default.
• W2065626701 cites W2007437575 @default.
• W2065626701 cites W2015089940 @default.
• W2065626701 cites W2051439285 @default.
• W2065626701 cites W2055214702 @default.
• W2065626701 cites W2055433724 @default.
• W2065626701 cites W2061102409 @default.
• W2065626701 cites W2061419918 @default.
• W2065626701 cites W2061680337 @default.
• W2065626701 cites W2067734328 @default.
• W2065626701 cites W2071501400 @default.
• W2065626701 cites W2093058636 @default.
• W2065626701 cites W2103017472 @default.
• W2065626701 cites W2103441770 @default.
• W2065626701 cites W2103662370 @default.
• W2065626701 cites W2103785441 @default.
• W2065626701 cites W2105199251 @default.
• W2065626701 cites W2107282968 @default.
• W2065626701 cites W2108929776 @default.
• W2065626701 cites W2112814753 @default.
• W2065626701 cites W2119497560 @default.
• W2065626701 cites W2129839012 @default.
• W2065626701 cites W2133790733 @default.
• W2065626701 cites W2135475671 @default.
• W2065626701 cites W2144342921 @default.
• W2065626701 cites W2146516445 @default.
• W2065626701 cites W2146728635 @default.
• W2065626701 cites W2148165706 @default.
• W2065626701 cites W2148853951 @default.
• W2065626701 cites W2154040307 @default.
• W2065626701 cites W2154431984 @default.
• W2065626701 cites W2158381555 @default.
• W2065626701 cites W2161546116 @default.
• W2065626701 cites W2161723277 @default.
• W2065626701 cites W2161923734 @default.
• W2065626701 cites W2164954378 @default.
• W2065626701 cites W2166574880 @default.
• W2065626701 cites W2169611847 @default.
• W2065626701 cites W2170949754 @default.
• W2065626701 cites W2171437346 @default.
• W2065626701 cites W2318665031 @default.
• W2065626701 cites W3080997834 @default.
• W2065626701 cites W4250052351 @default.
• W2065626701 cites W60515216 @default.
• W2065626701 doi "https://doi.org/10.1186/1471-2180-13-304" @default.
• W2065626701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3879163" @default.
• W2065626701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24373636" @default.
• W2065626701 hasPublicationYear "2013" @default.
• W2065626701 type Work @default.
• W2065626701 sameAs 2065626701 @default.
• W2065626701 citedByCount "15" @default.
• W2065626701 countsByYear W20656267012014 @default.
• W2065626701 countsByYear W20656267012015 @default.
• W2065626701 countsByYear W20656267012016 @default.
• W2065626701 countsByYear W20656267012017 @default.
• W2065626701 countsByYear W20656267012018 @default.
• W2065626701 countsByYear W20656267012020 @default.
• W2065626701 countsByYear W20656267012022 @default.
• W2065626701 countsByYear W20656267012023 @default.
• W2065626701 crossrefType "journal-article" @default.
• W2065626701 hasAuthorship W2065626701A5012278873 @default.
• W2065626701 hasAuthorship W2065626701A5014578752 @default.
• W2065626701 hasAuthorship W2065626701A5018735035 @default.
• W2065626701 hasAuthorship W2065626701A5023714026 @default.
• W2065626701 hasAuthorship W2065626701A5036837044 @default.
• W2065626701 hasAuthorship W2065626701A5045824135 @default.
• W2065626701 hasAuthorship W2065626701A5048718004 @default.
• W2065626701 hasAuthorship W2065626701A5054907664 @default.
• W2065626701 hasAuthorship W2065626701A5057739867 @default.
• W2065626701 hasAuthorship W2065626701A5059772660 @default.
• W2065626701 hasAuthorship W2065626701A5062907871 @default.
• W2065626701 hasAuthorship W2065626701A5067107917 @default.
• W2065626701 hasAuthorship W2065626701A5070568001 @default.
• W2065626701 hasAuthorship W2065626701A5077894708 @default.
• W2065626701 hasAuthorship W2065626701A5090159939 @default.
• W2065626701 hasBestOaLocation W20656267011 @default.

• next