FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065632425> ?p ?o ?g. }

• W2065632425 endingPage "5722" @default.
• W2065632425 startingPage "5717" @default.
• W2065632425 abstract "RNA-binding motif (RBM) genes are found on all mammalian Y chromosomes and are implicated in spermatogenesis. Within human germ cells, RBM protein shows a similar nuclear distribution to components of the pre-mRNA splicing machinery. To address the function of RBM, we have used protein-protein interaction assays to test for possible physical interactions between these proteins. We find that RBM protein directly interacts with members of the SR family of splicing factors and, in addition, strongly interacts with itself. We have mapped the protein domains responsible for mediating these interactions and expressed the mouse RBM interaction region as a bacterial fusion protein. This fusion protein can pull-down several functionally active SR protein species from cell extracts. Depletion and add-back experiments indicate that these SR proteins are the only splicing factors bound by RBM which are required for the splicing of a panel of pre-mRNAs. Our results suggest that RBM protein is an evolutionarily conserved mammalian splicing regulator which operates as a germ cell-specific cofactor for more ubiquitously expressed pre-mRNA splicing activators." @default.
• W2065632425 created "2016-06-24" @default.
• W2065632425 creator A5019858424 @default.
• W2065632425 creator A5039369417 @default.
• W2065632425 creator A5061350405 @default.
• W2065632425 creator A5067685732 @default.
• W2065632425 creator A5076537630 @default.
• W2065632425 date "2000-05-23" @default.
• W2065632425 modified "2023-10-13" @default.
• W2065632425 title "A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection" @default.
• W2065632425 cites W101837116 @default.
• W2065632425 cites W1264918545 @default.
• W2065632425 cites W1549656943 @default.
• W2065632425 cites W1583267914 @default.
• W2065632425 cites W1973916539 @default.
• W2065632425 cites W1977186059 @default.
• W2065632425 cites W1983800032 @default.
• W2065632425 cites W2012640439 @default.
• W2065632425 cites W2023542289 @default.
• W2065632425 cites W2026923004 @default.
• W2065632425 cites W2045959986 @default.
• W2065632425 cites W2080489609 @default.
• W2065632425 cites W2082491111 @default.
• W2065632425 cites W2084324047 @default.
• W2065632425 cites W2091936112 @default.
• W2065632425 cites W2103049574 @default.
• W2065632425 cites W2116884417 @default.
• W2065632425 cites W2117695381 @default.
• W2065632425 cites W2118994793 @default.
• W2065632425 cites W2121457746 @default.
• W2065632425 cites W2127739725 @default.
• W2065632425 cites W2128880818 @default.
• W2065632425 cites W2138346848 @default.
• W2065632425 cites W2141740778 @default.
• W2065632425 cites W2142122497 @default.
• W2065632425 cites W2151911735 @default.
• W2065632425 cites W2153199064 @default.
• W2065632425 cites W2168788116 @default.
• W2065632425 cites W2181901332 @default.
• W2065632425 cites W2240725506 @default.
• W2065632425 doi "https://doi.org/10.1073/pnas.97.11.5717" @default.
• W2065632425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/18499" @default.
• W2065632425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10823932" @default.
• W2065632425 hasPublicationYear "2000" @default.
• W2065632425 type Work @default.
• W2065632425 sameAs 2065632425 @default.
• W2065632425 citedByCount "57" @default.
• W2065632425 countsByYear W20656324252012 @default.
• W2065632425 countsByYear W20656324252013 @default.
• W2065632425 countsByYear W20656324252015 @default.
• W2065632425 countsByYear W20656324252019 @default.
• W2065632425 countsByYear W20656324252020 @default.
• W2065632425 countsByYear W20656324252022 @default.
• W2065632425 crossrefType "journal-article" @default.
• W2065632425 hasAuthorship W2065632425A5019858424 @default.
• W2065632425 hasAuthorship W2065632425A5039369417 @default.
• W2065632425 hasAuthorship W2065632425A5061350405 @default.
• W2065632425 hasAuthorship W2065632425A5067685732 @default.
• W2065632425 hasAuthorship W2065632425A5076537630 @default.
• W2065632425 hasBestOaLocation W20656324251 @default.
• W2065632425 hasConcept C104317684 @default.
• W2065632425 hasConcept C10447831 @default.
• W2065632425 hasConcept C105580179 @default.
• W2065632425 hasConcept C123894998 @default.
• W2065632425 hasConcept C194583182 @default.
• W2065632425 hasConcept C40767141 @default.
• W2065632425 hasConcept C41282012 @default.
• W2065632425 hasConcept C42576000 @default.
• W2065632425 hasConcept C54355233 @default.
• W2065632425 hasConcept C54458228 @default.
• W2065632425 hasConcept C67705224 @default.
• W2065632425 hasConcept C69551769 @default.
• W2065632425 hasConcept C86803240 @default.
• W2065632425 hasConcept C95444343 @default.
• W2065632425 hasConceptScore W2065632425C104317684 @default.
• W2065632425 hasConceptScore W2065632425C10447831 @default.
• W2065632425 hasConceptScore W2065632425C105580179 @default.
• W2065632425 hasConceptScore W2065632425C123894998 @default.
• W2065632425 hasConceptScore W2065632425C194583182 @default.
• W2065632425 hasConceptScore W2065632425C40767141 @default.
• W2065632425 hasConceptScore W2065632425C41282012 @default.
• W2065632425 hasConceptScore W2065632425C42576000 @default.
• W2065632425 hasConceptScore W2065632425C54355233 @default.
• W2065632425 hasConceptScore W2065632425C54458228 @default.
• W2065632425 hasConceptScore W2065632425C67705224 @default.
• W2065632425 hasConceptScore W2065632425C69551769 @default.
• W2065632425 hasConceptScore W2065632425C86803240 @default.
• W2065632425 hasConceptScore W2065632425C95444343 @default.
• W2065632425 hasIssue "11" @default.
• W2065632425 hasLocation W20656324251 @default.
• W2065632425 hasLocation W20656324252 @default.
• W2065632425 hasLocation W20656324253 @default.
• W2065632425 hasLocation W20656324254 @default.
• W2065632425 hasOpenAccess W2065632425 @default.
• W2065632425 hasPrimaryLocation W20656324251 @default.
• W2065632425 hasRelatedWork W1973158635 @default.
• W2065632425 hasRelatedWork W1975560388 @default.
• W2065632425 hasRelatedWork W1993816390 @default.

• next