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• W2065633657 abstract "The influence of hydroxypropyl beta-cyclodextrin (HPbetaCD) on the corneal permeation of pilocarpine nitrate was investigated by an in vitro permeability study using isolated rabbit cornea. Pupillary-response pattern to pilocarpine nitrate with and without HPbetaCD was examined in rabbit eye. Corneal permeation of pilocarpine nitrate was found to be four times higher after adding HPbetaCD into the formulation. The reduction of pupil diameter (miosis) by pilocarpine nitrate was significantly increased as a result of HPbetaCD addition into the simple aqueous solution of the active substance. The highest miotic response was obtained with the formulation prepared in a vehicle of Carbopol 940. It is suggested that ocular bioavailability of pilocarpine nitrate could be improved by the addition of HPbetaCD." @default.
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• W2065633657 date "2003-01-01" @default.
• W2065633657 modified "2023-10-10" @default.
• W2065633657 title "Influence of Hydroxypropyl β-Cyclodextrin on the Corneal Permeation of Pilocarpine" @default.
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• W2065633657 doi "https://doi.org/10.1081/ddc-120016730" @default.
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