FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065634468> ?p ?o ?g. }

• W2065634468 endingPage "44" @default.
• W2065634468 startingPage "37" @default.
• W2065634468 abstract "Transglutaminases (TGases) catalyze several reactions with protein substrates, including formation of gamma-glutamyl-epsilon-lysine cross-links and gamma-glutamylpolyamine residues. The resulting gamma-glutamylamines are excised intact during proteolysis. TGase activity is altered in several diseases, highlighting the importance of in situ enzymatic determinations. Previous work showed that TGase activity (as measured by an in vitro assay) and free gamma-glutamyl-epsilon-lysine levels are elevated in Huntington disease (HD) and that gamma-glutamyl-epsilon-lysine is increased in HD CSF. Although free gamma-glutamyl-epsilon-lysine was used in these studies as an index of in situ TGase activity, gamma-glutamylpolyamines may also be diagnostic. We have devised methods for the simultaneous determination of four gamma-glutamylamines in CSF: gamma-glutamyl-epsilon-lysine, gamma-glutamylspermidine, gamma-glutamylputrescine, and bis-gamma-glutamylputrescine and showed that all are present in normal human CSF at concentrations of approximately 150, 670, 40, and 240 nM, respectively. The high gamma-glutamylspermidine/gamma-glutamylputrescine and gamma-glutamylspermidine/bis-gamma-glutamylputrescine ratios presumably reflect in part the large spermidine to putrescine mole ratio in human brain. We also showed that all four gamma-glutamylamines are elevated in HD CSF. Our findings support the hypotheses that (i) gamma-glutamylpolyamines are reflective of TGase activity in human brain, (ii) polyamination is an important post-translational modification of brain proteins, and (iii) TGase-catalyzed modification of proteins is increased in HD brain." @default.
• W2065634468 created "2016-06-24" @default.
• W2065634468 creator A5051052158 @default.
• W2065634468 creator A5057468092 @default.
• W2065634468 creator A5074569290 @default.
• W2065634468 creator A5075714702 @default.
• W2065634468 creator A5086218531 @default.
• W2065634468 date "2008-04-18" @default.
• W2065634468 modified "2023-10-17" @default.
• W2065634468 title "Increased levels of γ-glutamylamines in Huntington disease CSF" @default.
• W2065634468 cites W1067939983 @default.
• W2065634468 cites W1486999320 @default.
• W2065634468 cites W1501599416 @default.
• W2065634468 cites W1515840075 @default.
• W2065634468 cites W1603852817 @default.
• W2065634468 cites W164897159 @default.
• W2065634468 cites W1879514944 @default.
• W2065634468 cites W1892455234 @default.
• W2065634468 cites W1967455040 @default.
• W2065634468 cites W1986960472 @default.
• W2065634468 cites W1993105690 @default.
• W2065634468 cites W1996843981 @default.
• W2065634468 cites W2006808229 @default.
• W2065634468 cites W2007801250 @default.
• W2065634468 cites W2008489714 @default.
• W2065634468 cites W2009648536 @default.
• W2065634468 cites W2022705009 @default.
• W2065634468 cites W2023135519 @default.
• W2065634468 cites W2023451633 @default.
• W2065634468 cites W2027172959 @default.
• W2065634468 cites W2028374104 @default.
• W2065634468 cites W2036485096 @default.
• W2065634468 cites W2050719645 @default.
• W2065634468 cites W2051788484 @default.
• W2065634468 cites W2054749434 @default.
• W2065634468 cites W2057091932 @default.
• W2065634468 cites W2060750433 @default.
• W2065634468 cites W2067403820 @default.
• W2065634468 cites W2072392419 @default.
• W2065634468 cites W2073255828 @default.
• W2065634468 cites W2074782316 @default.
• W2065634468 cites W2080891856 @default.
• W2065634468 cites W2086495955 @default.
• W2065634468 cites W2086710992 @default.
• W2065634468 cites W2091265379 @default.
• W2065634468 cites W2138780723 @default.
• W2065634468 cites W2144921146 @default.
• W2065634468 cites W2146891310 @default.
• W2065634468 cites W2153232303 @default.
• W2065634468 cites W2161688885 @default.
• W2065634468 cites W2215022012 @default.
• W2065634468 cites W2404140781 @default.
• W2065634468 doi "https://doi.org/10.1111/j.1471-4159.2008.05350.x" @default.
• W2065634468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2574808" @default.
• W2065634468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18422943" @default.
• W2065634468 hasPublicationYear "2008" @default.
• W2065634468 type Work @default.
• W2065634468 sameAs 2065634468 @default.
• W2065634468 citedByCount "55" @default.
• W2065634468 countsByYear W20656344682012 @default.
• W2065634468 countsByYear W20656344682013 @default.
• W2065634468 countsByYear W20656344682014 @default.
• W2065634468 countsByYear W20656344682015 @default.
• W2065634468 countsByYear W20656344682016 @default.
• W2065634468 countsByYear W20656344682017 @default.
• W2065634468 countsByYear W20656344682018 @default.
• W2065634468 countsByYear W20656344682020 @default.
• W2065634468 countsByYear W20656344682021 @default.
• W2065634468 crossrefType "journal-article" @default.
• W2065634468 hasAuthorship W2065634468A5051052158 @default.
• W2065634468 hasAuthorship W2065634468A5057468092 @default.
• W2065634468 hasAuthorship W2065634468A5074569290 @default.
• W2065634468 hasAuthorship W2065634468A5075714702 @default.
• W2065634468 hasAuthorship W2065634468A5086218531 @default.
• W2065634468 hasBestOaLocation W20656344681 @default.
• W2065634468 hasConcept C153911025 @default.
• W2065634468 hasConcept C178498320 @default.
• W2065634468 hasConcept C181199279 @default.
• W2065634468 hasConcept C185592680 @default.
• W2065634468 hasConcept C202751555 @default.
• W2065634468 hasConcept C2776016237 @default.
• W2065634468 hasConcept C2777497464 @default.
• W2065634468 hasConcept C2781307694 @default.
• W2065634468 hasConcept C515207424 @default.
• W2065634468 hasConcept C55493867 @default.
• W2065634468 hasConcept C86803240 @default.
• W2065634468 hasConceptScore W2065634468C153911025 @default.
• W2065634468 hasConceptScore W2065634468C178498320 @default.
• W2065634468 hasConceptScore W2065634468C181199279 @default.
• W2065634468 hasConceptScore W2065634468C185592680 @default.
• W2065634468 hasConceptScore W2065634468C202751555 @default.
• W2065634468 hasConceptScore W2065634468C2776016237 @default.
• W2065634468 hasConceptScore W2065634468C2777497464 @default.
• W2065634468 hasConceptScore W2065634468C2781307694 @default.
• W2065634468 hasConceptScore W2065634468C515207424 @default.
• W2065634468 hasConceptScore W2065634468C55493867 @default.
• W2065634468 hasConceptScore W2065634468C86803240 @default.
• W2065634468 hasIssue "1" @default.

• next