FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065634926> ?p ?o ?g. }

• W2065634926 endingPage "252" @default.
• W2065634926 startingPage "243" @default.
• W2065634926 abstract "Glaucoma, a leading cause of blindness, is a neurodegenerative disease characterized by progressive loss of retinal ganglion cell axons in the optic nerve and their cell bodies in the retina. Reactive retinal glial changes have been observed in glaucoma but the role of such glial changes in the pathogenesis of the condition remains unclear. In the present study we found that retinal ganglion cells in an experimental animal model of glaucoma have an increased axon regenerative potential. Regeneration of adult rat retinal ganglion cell axons after optic nerve crush was significantly increased in vivo when combined with intraocular pressure-induced experimental glaucoma. This enhanced axon regeneration response was correlated with a significant increase in activation of glial fibrillary acidic protein+retinal glia. Using a dissociated retinal ganglion cell culture model we showed that reducing the number of activated retinal glia with a glial specific toxin, α-Aminoadipic acid, significantly reduced the growth potential of retinal ganglion cells from glaucomatous rat eyes, suggesting that activated retinal glia mediate, at least in part, the growth promoting effect. This was shown to be mediated by both membrane-bound and soluble glial-derived factors. Neurotrophin and ciliary neurotrophic/leukemia inhibitory factor blockers did not affect the regenerative potential, excluding these growth factors as principal mediators of the enhanced growth response occurring in glaucomatous retinal cultures. These observations are the first to reveal that retinal ganglion cells from glaucomatous rat eyes have an enhanced regenerative capacity. Furthermore, our results suggest that activated retinal glia mediate at least part of this response. Further work to understand and enhance the regeneration-promoting effect of activated retinal glia is required to determine if this approach could be useful as part of a therapeutic strategy to encourage optic nerve regeneration in glaucoma." @default.
• W2065634926 created "2016-06-24" @default.
• W2065634926 creator A5001622337 @default.
• W2065634926 creator A5007382759 @default.
• W2065634926 creator A5022721130 @default.
• W2065634926 creator A5051316175 @default.
• W2065634926 date "2012-01-01" @default.
• W2065634926 modified "2023-09-23" @default.
• W2065634926 title "Activated retinal glia mediated axon regeneration in experimental glaucoma" @default.
• W2065634926 cites W1675594938 @default.
• W2065634926 cites W1842081459 @default.
• W2065634926 cites W1861582625 @default.
• W2065634926 cites W1952373745 @default.
• W2065634926 cites W1966040258 @default.
• W2065634926 cites W1969565540 @default.
• W2065634926 cites W1972343445 @default.
• W2065634926 cites W1977739438 @default.
• W2065634926 cites W1978354922 @default.
• W2065634926 cites W1982255088 @default.
• W2065634926 cites W1983422848 @default.
• W2065634926 cites W1986657126 @default.
• W2065634926 cites W1987590420 @default.
• W2065634926 cites W1991286437 @default.
• W2065634926 cites W1991343786 @default.
• W2065634926 cites W1994464552 @default.
• W2065634926 cites W1996243257 @default.
• W2065634926 cites W2004873076 @default.
• W2065634926 cites W2004947473 @default.
• W2065634926 cites W2012916694 @default.
• W2065634926 cites W2015708374 @default.
• W2065634926 cites W2023402827 @default.
• W2065634926 cites W2024882749 @default.
• W2065634926 cites W2027759472 @default.
• W2065634926 cites W2029994336 @default.
• W2065634926 cites W2030068872 @default.
• W2065634926 cites W2037561740 @default.
• W2065634926 cites W2039328257 @default.
• W2065634926 cites W2052439242 @default.
• W2065634926 cites W2055741851 @default.
• W2065634926 cites W2055843986 @default.
• W2065634926 cites W2057266151 @default.
• W2065634926 cites W2057502749 @default.
• W2065634926 cites W2058050891 @default.
• W2065634926 cites W2065142041 @default.
• W2065634926 cites W2072171413 @default.
• W2065634926 cites W2073762882 @default.
• W2065634926 cites W2075881876 @default.
• W2065634926 cites W2076736059 @default.
• W2065634926 cites W2078310962 @default.
• W2065634926 cites W2084891008 @default.
• W2065634926 cites W2086603235 @default.
• W2065634926 cites W2090422278 @default.
• W2065634926 cites W2092157383 @default.
• W2065634926 cites W2095816451 @default.
• W2065634926 cites W2096448283 @default.
• W2065634926 cites W2097325660 @default.
• W2065634926 cites W2101679513 @default.
• W2065634926 cites W2104765841 @default.
• W2065634926 cites W2122477596 @default.
• W2065634926 cites W2135551394 @default.
• W2065634926 cites W2145558392 @default.
• W2065634926 cites W2147804863 @default.
• W2065634926 cites W2159123872 @default.
• W2065634926 cites W2163599338 @default.
• W2065634926 cites W33441858 @default.
• W2065634926 cites W4212783369 @default.
• W2065634926 cites W4242731554 @default.
• W2065634926 cites W4246878943 @default.
• W2065634926 cites W4297755600 @default.
• W2065634926 doi "https://doi.org/10.1016/j.nbd.2011.08.008" @default.
• W2065634926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21867754" @default.
• W2065634926 hasPublicationYear "2012" @default.
• W2065634926 type Work @default.
• W2065634926 sameAs 2065634926 @default.
• W2065634926 citedByCount "25" @default.
• W2065634926 countsByYear W20656349262012 @default.
• W2065634926 countsByYear W20656349262013 @default.
• W2065634926 countsByYear W20656349262014 @default.
• W2065634926 countsByYear W20656349262015 @default.
• W2065634926 countsByYear W20656349262016 @default.
• W2065634926 countsByYear W20656349262017 @default.
• W2065634926 countsByYear W20656349262018 @default.
• W2065634926 countsByYear W20656349262019 @default.
• W2065634926 crossrefType "journal-article" @default.
• W2065634926 hasAuthorship W2065634926A5001622337 @default.
• W2065634926 hasAuthorship W2065634926A5007382759 @default.
• W2065634926 hasAuthorship W2065634926A5022721130 @default.
• W2065634926 hasAuthorship W2065634926A5051316175 @default.
• W2065634926 hasConcept C160539049 @default.
• W2065634926 hasConcept C169760540 @default.
• W2065634926 hasConcept C170493617 @default.
• W2065634926 hasConcept C171056886 @default.
• W2065634926 hasConcept C177275483 @default.
• W2065634926 hasConcept C203014093 @default.
• W2065634926 hasConcept C204232928 @default.
• W2065634926 hasConcept C2777093970 @default.
• W2065634926 hasConcept C2777624874 @default.
• W2065634926 hasConcept C2779530196 @default.

• next