FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065640159> ?p ?o ?g. }

• W2065640159 endingPage "e1000926" @default.
• W2065640159 startingPage "e1000926" @default.
• W2065640159 abstract "In eukaryotic cells, the internalization of extracellular cargo via the endocytic machinery is an important regulatory process required for many essential cellular functions. The role of cooperative protein-protein and protein-membrane interactions in the ubiquitous endocytic pathway in mammalian cells, namely the clathrin-dependent endocytosis, remains unresolved. We employ the Helfrich membrane Hamiltonian together with surface evolution methodology to address how the shapes and energetics of vesicular-bud formation in a planar membrane are stabilized by presence of the clathrin-coat assembly. Our results identify a unique dual role for the tubulating protein epsin: multiple epsins localized spatially and orientationally collectively play the role of a curvature inducing capsid; in addition, epsin serves the role of an adapter in binding the clathrin coat to the membrane. Our results also suggest an important role for the clathrin lattice, namely in the spatial- and orientational-templating of epsins. We suggest that there exists a critical size of the coat above which a vesicular bud with a constricted neck resembling a mature vesicle is stabilized. Based on the observed strong dependence of the vesicle diameter on the bending rigidity, we suggest that the variability in bending stiffness due to variations in membrane composition with cell type can explain the experimentally observed variability on the size of clathrin-coated vesicles, which typically range 50–100 nm. Our model also provides estimates for the number of epsins involved in stabilizing a coated vesicle, and without any direct fitting reproduces the experimentally observed shapes of vesicular intermediates as well as their probability distributions quantitatively, in wildtype as well as CLAP IgG injected neuronal cell experiments. We have presented a minimal mesoscale model which quantitatively explains several experimental observations on the process of vesicle nucleation induced by the clathrin-coated assembly prior to vesicle scission in clathrin dependent endocytosis." @default.
• W2065640159 created "2016-06-24" @default.
• W2065640159 creator A5007843560 @default.
• W2065640159 creator A5037007496 @default.
• W2065640159 creator A5041625801 @default.
• W2065640159 date "2010-09-09" @default.
• W2065640159 modified "2023-10-15" @default.
• W2065640159 title "Minimal Mesoscale Model for Protein-Mediated Vesiculation in Clathrin-Dependent Endocytosis" @default.
• W2065640159 cites W1491787713 @default.
• W2065640159 cites W1967128568 @default.
• W2065640159 cites W1975118992 @default.
• W2065640159 cites W1986700361 @default.
• W2065640159 cites W1988541190 @default.
• W2065640159 cites W1993485325 @default.
• W2065640159 cites W1993676528 @default.
• W2065640159 cites W1995950736 @default.
• W2065640159 cites W1999349178 @default.
• W2065640159 cites W2000545789 @default.
• W2065640159 cites W2001532503 @default.
• W2065640159 cites W2002940846 @default.
• W2065640159 cites W2004407285 @default.
• W2065640159 cites W2005300555 @default.
• W2065640159 cites W2012107438 @default.
• W2065640159 cites W2019040974 @default.
• W2065640159 cites W2019450224 @default.
• W2065640159 cites W2021221687 @default.
• W2065640159 cites W2023888329 @default.
• W2065640159 cites W2025361378 @default.
• W2065640159 cites W2032444338 @default.
• W2065640159 cites W2035042024 @default.
• W2065640159 cites W2035179559 @default.
• W2065640159 cites W2040438591 @default.
• W2065640159 cites W2052881002 @default.
• W2065640159 cites W2066978513 @default.
• W2065640159 cites W2070541534 @default.
• W2065640159 cites W2071725693 @default.
• W2065640159 cites W2074969527 @default.
• W2065640159 cites W2096154351 @default.
• W2065640159 cites W2106474898 @default.
• W2065640159 cites W2107853353 @default.
• W2065640159 cites W2113732463 @default.
• W2065640159 cites W2114628856 @default.
• W2065640159 cites W2115994196 @default.
• W2065640159 cites W2120670306 @default.
• W2065640159 cites W2124185690 @default.
• W2065640159 cites W2125123295 @default.
• W2065640159 cites W2134283668 @default.
• W2065640159 cites W2136509538 @default.
• W2065640159 cites W2145559584 @default.
• W2065640159 cites W2155190462 @default.
• W2065640159 cites W2155657795 @default.
• W2065640159 cites W2169662947 @default.
• W2065640159 cites W2264936970 @default.
• W2065640159 cites W3104513148 @default.
• W2065640159 cites W3106178426 @default.
• W2065640159 doi "https://doi.org/10.1371/journal.pcbi.1000926" @default.
• W2065640159 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2936510" @default.
• W2065640159 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20838575" @default.
• W2065640159 hasPublicationYear "2010" @default.
• W2065640159 type Work @default.
• W2065640159 sameAs 2065640159 @default.
• W2065640159 citedByCount "45" @default.
• W2065640159 countsByYear W20656401592012 @default.
• W2065640159 countsByYear W20656401592013 @default.
• W2065640159 countsByYear W20656401592014 @default.
• W2065640159 countsByYear W20656401592015 @default.
• W2065640159 countsByYear W20656401592016 @default.
• W2065640159 countsByYear W20656401592017 @default.
• W2065640159 countsByYear W20656401592018 @default.
• W2065640159 countsByYear W20656401592019 @default.
• W2065640159 countsByYear W20656401592020 @default.
• W2065640159 countsByYear W20656401592021 @default.
• W2065640159 countsByYear W20656401592022 @default.
• W2065640159 countsByYear W20656401592023 @default.
• W2065640159 crossrefType "journal-article" @default.
• W2065640159 hasAuthorship W2065640159A5007843560 @default.
• W2065640159 hasAuthorship W2065640159A5037007496 @default.
• W2065640159 hasAuthorship W2065640159A5041625801 @default.
• W2065640159 hasBestOaLocation W20656401591 @default.
• W2065640159 hasConcept C12554922 @default.
• W2065640159 hasConcept C130316041 @default.
• W2065640159 hasConcept C1491633281 @default.
• W2065640159 hasConcept C2777278457 @default.
• W2065640159 hasConcept C28005876 @default.
• W2065640159 hasConcept C41625074 @default.
• W2065640159 hasConcept C55493867 @default.
• W2065640159 hasConcept C63162447 @default.
• W2065640159 hasConcept C79747257 @default.
• W2065640159 hasConcept C86803240 @default.
• W2065640159 hasConcept C95444343 @default.
• W2065640159 hasConceptScore W2065640159C12554922 @default.
• W2065640159 hasConceptScore W2065640159C130316041 @default.
• W2065640159 hasConceptScore W2065640159C1491633281 @default.
• W2065640159 hasConceptScore W2065640159C2777278457 @default.
• W2065640159 hasConceptScore W2065640159C28005876 @default.
• W2065640159 hasConceptScore W2065640159C41625074 @default.
• W2065640159 hasConceptScore W2065640159C55493867 @default.
• W2065640159 hasConceptScore W2065640159C63162447 @default.

• next