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• W2065642267 abstract "The occurrence of neonatal goiter or hypothyroidism is described in two sets of dizygotic twins born tothyrotoxic mothers treated with antithyroid drugs during gestation. In the first set of twins, one presented with a transient though significant goiter in the presence of slightly diminished level of serum free thyroxine. In the second set, one twin also had a transient though significant depression in serum free thyroxine. In both instances, only the affected infant had transient elevation of serum thyrotropin as measured by immunoassay and/or bioassay. Thus, for the first time, the hypothesis that antithyroid drugs cause thyroid hyperplasia in the human fetus by the stimulation of fetal pituitary thyrotropin has been confirmed. Possible factors responsible for the selective effect of antithyroid drugs in one member of each set of twins are discussed. The occurrence of neonatal goiter or hypothyroidism is described in two sets of dizygotic twins born tothyrotoxic mothers treated with antithyroid drugs during gestation. In the first set of twins, one presented with a transient though significant goiter in the presence of slightly diminished level of serum free thyroxine. In the second set, one twin also had a transient though significant depression in serum free thyroxine. In both instances, only the affected infant had transient elevation of serum thyrotropin as measured by immunoassay and/or bioassay. Thus, for the first time, the hypothesis that antithyroid drugs cause thyroid hyperplasia in the human fetus by the stimulation of fetal pituitary thyrotropin has been confirmed. Possible factors responsible for the selective effect of antithyroid drugs in one member of each set of twins are discussed." @default.
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• W2065642267 date "1974-08-01" @default.
• W2065642267 modified "2023-09-26" @default.
• W2065642267 title "Neonatal hypothyroidism and goiter in oneinfant of each of two sets of twins due to maternal therapy with antithyroid drugs" @default.
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• W2065642267 doi "https://doi.org/10.1016/s0022-3476(74)80404-x" @default.
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