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• W2065645470 abstract "Microinjection of ibotenic acid into medial septum of rats decreased choline acetyltransferase (CAT) and high-affinity choline uptake (HACU) activities in hippocampus and retarded the learning of a spatial memory task in the radial-arm maze. Administration of MK-771, a stable TRH analog, to such animals restored HACU activity in hippocampus to normal levels. Daily treatment of rats with MK-771 prior to maze running also restored the animals' learning ability. MK-771 did not enhance hippocampal HACU activity or maze performance in sham-lesioned rats. These results suggest that MK-771 reversed the ibotenic acid-induced memory deficit by restoring septohippocampal cholinergic function. MK-771 and other TRH analogs may represent novel agents for improving memory deficits produced by cholinergic insufficiency in Alzheimer's disease." @default.
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• W2065645470 date "1989-01-01" @default.
• W2065645470 modified "2023-10-08" @default.
• W2065645470 title "TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesioned rats" @default.
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• W2065645470 doi "https://doi.org/10.1016/0196-9781(89)90087-9" @default.
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