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• W2065646591 abstract "Germline mutations in the putative tumor suppressor gene,BRCA1,predispose women to dramatically elevated risks of breast cancer, while germline mutations in the structurally unrelated gene,BRCA2,predispose both men and women to breast cancer. Recent studies have suggested an important developmental role for the murine homologue ofBRCA1in the regulation of proliferation and differentiation. At the present time, however, little is known about the developmental role ofBRCA2or the regulation of its expressionin vivo.We have determined the spatial and temporal pattern of expression of the murine homologue ofBRCA2during fetal development, in adult tissues, and in the mammary gland during postnatal development. Our results indicate thatBrca2mRNA expression is highest in proliferating cellular compartments, particularly those undergoing differentiation. In the breast,Brca2expression is developmentally regulated and is induced during puberty and pregnancy and as a result of parity. Surprisingly, in multiple fetal and adult tissues the spatial and temporal pattern ofBrca2mRNA expression is virtually indistinguishable from that ofBrca1,despite the fact that these genes display no homology. These observations suggest thatBrca2is involved in the processes of proliferation and differentiation in the mammary gland and other tissues, and thatBrca1andBrca2mRNA expression may be regulated by similar pathways and stimuli in multiple cell types. Interestingly, however, our analysis reveals thatBrca1andBrca2expression are differentially regulated during the development of specific endocrine target tissues, such as the testis during spermatogenesis and the breast during pregnancy. In addition, the ratio of mRNA expression in the mammary glands of adult females relative to adult males is significantly greater forBrca1than forBrca2.These observations imply thatBrca1andBrca2mRNA expression are differentially regulated by sex hormones. In order to test this hypothesis, we have analyzed the expression of these two breast cancer susceptibility genes in ovariectomized mice treated with 17β-estradiol and progesterone. Our results demonstrate that the up-regulation of mRNA expression in the breast by ovarian hormones is significantly greater forBrca1than forBrca2.These observations suggest that the gender-specific differences in phenotype associated with germline mutations inBRCA2versusBRCA1may be related to the differential regulation of these genes by sex hormones." @default.
• W2065646591 created "2016-06-24" @default.
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• W2065646591 date "1997-04-01" @default.
• W2065646591 modified "2023-10-13" @default.
• W2065646591 title "Developmental Expression ofBrca2Colocalizes withBrca1and Is Associated with Proliferation and Differentiation in Multiple Tissues" @default.
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• W2065646591 doi "https://doi.org/10.1006/dbio.1997.8526" @default.
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