Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065646722> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2065646722 endingPage "480" @default.
- W2065646722 startingPage "478" @default.
- W2065646722 abstract "Molecular processes regulating the gain of NMDA receptors modulate diverse physiological and pathological responses in the CNS. Group I metabotropic glutamate receptors (mGluRs), which neighbor NMDA receptors and which can be coactivated by synaptically released glutamate, couple to several different second messenger pathways, each of which could target NMDA receptors. In CA3 pyramidal cells we show that the activation of mGluR1 potentiates NMDA current via a G-protein-independent mechanism involving Src kinase activation. In contrast, mGluR5-mediated enhancement of NMDA current requires G-protein activation, triggering a signaling cascade including protein kinase C and Src. These results indicate that one neurotransmitter, glutamate, can activate two distinct and independent signaling systems to target the same effector. These two pathways are likely to contribute significantly to the highly differentiated control of NMDA receptor function." @default.
- W2065646722 created "2016-06-24" @default.
- W2065646722 creator A5056979204 @default.
- W2065646722 date "1969-11-22" @default.
- W2065646722 modified "2023-09-24" @default.
- W2065646722 title "Extrication of trapped casualties." @default.
- W2065646722 doi "https://doi.org/10.1136/bmj.4.5681.478" @default.
- W2065646722 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1630528" @default.
- W2065646722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5354838" @default.
- W2065646722 hasPublicationYear "1969" @default.
- W2065646722 type Work @default.
- W2065646722 sameAs 2065646722 @default.
- W2065646722 citedByCount "8" @default.
- W2065646722 countsByYear W20656467222012 @default.
- W2065646722 countsByYear W20656467222016 @default.
- W2065646722 crossrefType "journal-article" @default.
- W2065646722 hasAuthorship W2065646722A5056979204 @default.
- W2065646722 hasBestOaLocation W20656467221 @default.
- W2065646722 hasConcept C136764020 @default.
- W2065646722 hasConcept C2522767166 @default.
- W2065646722 hasConcept C38652104 @default.
- W2065646722 hasConcept C41008148 @default.
- W2065646722 hasConcept C545542383 @default.
- W2065646722 hasConcept C71924100 @default.
- W2065646722 hasConceptScore W2065646722C136764020 @default.
- W2065646722 hasConceptScore W2065646722C2522767166 @default.
- W2065646722 hasConceptScore W2065646722C38652104 @default.
- W2065646722 hasConceptScore W2065646722C41008148 @default.
- W2065646722 hasConceptScore W2065646722C545542383 @default.
- W2065646722 hasConceptScore W2065646722C71924100 @default.
- W2065646722 hasIssue "5681" @default.
- W2065646722 hasLocation W20656467221 @default.
- W2065646722 hasLocation W20656467222 @default.
- W2065646722 hasLocation W20656467223 @default.
- W2065646722 hasLocation W20656467224 @default.
- W2065646722 hasLocation W20656467225 @default.
- W2065646722 hasOpenAccess W2065646722 @default.
- W2065646722 hasPrimaryLocation W20656467221 @default.
- W2065646722 hasRelatedWork W2130043461 @default.
- W2065646722 hasRelatedWork W2323581027 @default.
- W2065646722 hasRelatedWork W2350741829 @default.
- W2065646722 hasRelatedWork W2358668433 @default.
- W2065646722 hasRelatedWork W2376932109 @default.
- W2065646722 hasRelatedWork W2382290278 @default.
- W2065646722 hasRelatedWork W2390279801 @default.
- W2065646722 hasRelatedWork W2748952813 @default.
- W2065646722 hasRelatedWork W2899084033 @default.
- W2065646722 hasRelatedWork W2530322880 @default.
- W2065646722 hasVolume "4" @default.
- W2065646722 isParatext "false" @default.
- W2065646722 isRetracted "false" @default.
- W2065646722 magId "2065646722" @default.
- W2065646722 workType "article" @default.