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- W2065647520 abstract "Resin acids, forming a major component of wood industry, cause numerous toxic effects on liver and red blood cells of fish. Effect of dehydroabietic acid (DHAA) on erythrocyte pH of river lamprey was investigated using [14C]DMO distribution to determine pHi. Exposure of the cells to more than 200 μM DHAA caused hemolysis within 10 min of incubation. Treatment with 50–200 μM DHAA resulted in a rapid dose-dependent decrease in erythrocyte pH. DHAA-induced reduction of pHi was dependent on pH of the extracellular medium. Application of 100 μM DHAA caused a 0.13 units drop of intracellular pH at pHo 8.0, 0.20 units at pHo 7.6, and 0.35 units at pHo 6.5. Cell pH was a saturable function of concentration of the uncharged form of DHAA (different concentrations of the uncharged form reached by varying of DHAA (total) concentrations and extracellular pH) with a rapid decline in pHi from 8.0 to 7.2 at 3–4 μM concentration of the resin acid followed by modest pHi change at concentrations exceeding 10 μM. DHAA-induced acidification was reversible with pHi returning to control values in 15 min after removal of DHAAo. The DHAA effect on cell pH was not due to inhibition of Na+/H+ exchanger. Two alternative mechanisms of DHAA action suggested are: alteration of membrane permeability to proton equivalents due to incorporation of DHAA into the lipid bilayer or carrier-like mode of penetration of the uncharged form of DHAA into the cell with the following dissociation." @default.
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- W2065647520 date "1998-10-01" @default.
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- W2065647520 title "Dehydroabietic acid, a major effluent component of paper and pulp industry, decreases erythrocyte pH in lamprey (Lampetra fluviatilis)" @default.
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- W2065647520 doi "https://doi.org/10.1016/s0166-445x(98)00057-5" @default.
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