FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065647550> ?p ?o ?g. }

• W2065647550 abstract "Merkel cell carcinoma is a rare skin malignancy, which primarily affects the elderly. Currently, there is only limited data on the natural history of this condition and no consensus on its optimum management. We have reviewed the natural history and management of 22 patients with Merkel cell carcinoma, who were treated at the Royal Marsden Hospital between 1985 and 1994. The median age at diagnosis was 75 years (range 55-96), with the head and neck region being the most common site of disease (nine patients: 41%). Seventeen patients (77%) presented with skin disease, three (14%) with regional lymphadenopathy and two (9%) with metastatic disease. Of the Stage I patients, 41% developed local recurrence postoperatively at a median time to relapse of 12 months. Those with head and neck disease had the highest risk of local recurrence, which occurred in 62.5% of this group. Stage I patients also had a high risk of disease progression, with 53% developing regional lymphadenopathy or visceral metastases. The median survival for all disease stages was 47 months. The treatment of unresectable primary or recurrent disease with radiotherapy led to valuable long term control in four of nine patients treated. Six courses of chemotherapy were administered; one brief complete response was observed, occurring in a patient treated with cyclophosphamide, vincristine and doxorubicin. The data in this study confirms the predilection for the elderly and the aggressive nature of Merkel cell carcinoma, with only four of 17 Stage I patients remaining disease free. To clarify the role of adjuvant postoperative radiotherapy and to establish the appropriate use of chemotherapy in metastatic spread of this rare malignancy will require further studies with multicentre cooperation." @default.
• W2065647550 created "2016-06-24" @default.
• W2065647550 creator A5033553843 @default.
• W2065647550 creator A5063293745 @default.
• W2065647550 creator A5084162980 @default.
• W2065647550 creator A5086837303 @default.
• W2065647550 creator A5087114740 @default.
• W2065647550 date "1997-01-01" @default.
• W2065647550 modified "2023-09-26" @default.
• W2065647550 title "The natural history and management of Merkel cell carcinoma of the skin: A review of 22 patients treated at the Royal Marsden Hospital" @default.
• W2065647550 cites W1964485250 @default.
• W2065647550 cites W1967538835 @default.
• W2065647550 cites W1986932974 @default.
• W2065647550 cites W1990202296 @default.
• W2065647550 cites W1999352445 @default.
• W2065647550 cites W1999485339 @default.
• W2065647550 cites W2017991867 @default.
• W2065647550 cites W2060836595 @default.
• W2065647550 cites W2061900093 @default.
• W2065647550 cites W2065119979 @default.
• W2065647550 cites W2078952368 @default.
• W2065647550 cites W2079436918 @default.
• W2065647550 cites W2081315844 @default.
• W2065647550 cites W2091899236 @default.
• W2065647550 cites W2126063371 @default.
• W2065647550 cites W2135955308 @default.
• W2065647550 cites W2145048826 @default.
• W2065647550 cites W2160187361 @default.
• W2065647550 cites W4254233664 @default.
• W2065647550 doi "https://doi.org/10.1016/s0936-6555(97)80073-8" @default.
• W2065647550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9269548" @default.
• W2065647550 hasPublicationYear "1997" @default.
• W2065647550 type Work @default.
• W2065647550 sameAs 2065647550 @default.
• W2065647550 citedByCount "51" @default.
• W2065647550 countsByYear W20656475502012 @default.
• W2065647550 countsByYear W20656475502013 @default.
• W2065647550 countsByYear W20656475502014 @default.
• W2065647550 countsByYear W20656475502017 @default.
• W2065647550 crossrefType "journal-article" @default.
• W2065647550 hasAuthorship W2065647550A5033553843 @default.
• W2065647550 hasAuthorship W2065647550A5063293745 @default.
• W2065647550 hasAuthorship W2065647550A5084162980 @default.
• W2065647550 hasAuthorship W2065647550A5086837303 @default.
• W2065647550 hasAuthorship W2065647550A5087114740 @default.
• W2065647550 hasConcept C121608353 @default.
• W2065647550 hasConcept C126322002 @default.
• W2065647550 hasConcept C141071460 @default.
• W2065647550 hasConcept C146357865 @default.
• W2065647550 hasConcept C151730666 @default.
• W2065647550 hasConcept C163276114 @default.
• W2065647550 hasConcept C2776694085 @default.
• W2065647550 hasConcept C2776755627 @default.
• W2065647550 hasConcept C2777546739 @default.
• W2065647550 hasConcept C2778162587 @default.
• W2065647550 hasConcept C2778342957 @default.
• W2065647550 hasConcept C2779134260 @default.
• W2065647550 hasConcept C2779399171 @default.
• W2065647550 hasConcept C2779429289 @default.
• W2065647550 hasConcept C2780192828 @default.
• W2065647550 hasConcept C2780291066 @default.
• W2065647550 hasConcept C509974204 @default.
• W2065647550 hasConcept C71924100 @default.
• W2065647550 hasConcept C86803240 @default.
• W2065647550 hasConceptScore W2065647550C121608353 @default.
• W2065647550 hasConceptScore W2065647550C126322002 @default.
• W2065647550 hasConceptScore W2065647550C141071460 @default.
• W2065647550 hasConceptScore W2065647550C146357865 @default.
• W2065647550 hasConceptScore W2065647550C151730666 @default.
• W2065647550 hasConceptScore W2065647550C163276114 @default.
• W2065647550 hasConceptScore W2065647550C2776694085 @default.
• W2065647550 hasConceptScore W2065647550C2776755627 @default.
• W2065647550 hasConceptScore W2065647550C2777546739 @default.
• W2065647550 hasConceptScore W2065647550C2778162587 @default.
• W2065647550 hasConceptScore W2065647550C2778342957 @default.
• W2065647550 hasConceptScore W2065647550C2779134260 @default.
• W2065647550 hasConceptScore W2065647550C2779399171 @default.
• W2065647550 hasConceptScore W2065647550C2779429289 @default.
• W2065647550 hasConceptScore W2065647550C2780192828 @default.
• W2065647550 hasConceptScore W2065647550C2780291066 @default.
• W2065647550 hasConceptScore W2065647550C509974204 @default.
• W2065647550 hasConceptScore W2065647550C71924100 @default.
• W2065647550 hasConceptScore W2065647550C86803240 @default.
• W2065647550 hasLocation W20656475501 @default.
• W2065647550 hasLocation W20656475502 @default.
• W2065647550 hasOpenAccess W2065647550 @default.
• W2065647550 hasPrimaryLocation W20656475501 @default.
• W2065647550 hasRelatedWork W114417029 @default.
• W2065647550 hasRelatedWork W1966841381 @default.
• W2065647550 hasRelatedWork W2057537503 @default.
• W2065647550 hasRelatedWork W2065647550 @default.
• W2065647550 hasRelatedWork W2072617176 @default.
• W2065647550 hasRelatedWork W2230522317 @default.
• W2065647550 hasRelatedWork W2321118795 @default.
• W2065647550 hasRelatedWork W2396969100 @default.
• W2065647550 hasRelatedWork W2412245030 @default.
• W2065647550 hasRelatedWork W4289968232 @default.
• W2065647550 isParatext "false" @default.
• W2065647550 isRetracted "false" @default.
• W2065647550 magId "2065647550" @default.

• next