Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065647657> ?p ?o ?g. }
- W2065647657 endingPage "138" @default.
- W2065647657 startingPage "130" @default.
- W2065647657 abstract "Coronary heart disease causes obstruction of coronary blood flow and is the leading cause of death worldwide. The effect of focal stenosis on downstream flow pattern in the coronary arterial tree is not well understood. Here, the blood flows in normal and diseased porcine left anterior descending (LAD) arterial tree were modeled and compared to determine the effects of stenosis on the blood flow distribution and hemodynamic parameters. The anatomical model of LAD was extracted from a porcine heart by computed tomography (CT), which was comprised of a main trunk and nine side branches. Stenoses with various severities were imposed into the main trunk between the first and second side branches, and the boundary condition at each outlet accounted for the effect of stenosis on the flow rate in the downstream vasculature. It was found that only significant stenosis (≥75% area reduction) considerably altered pressure drop and total flow rate distribution in branches and at each bifurcation. The effect of significant stenosis on bifurcations, however, diminished at downstream locations. As demonstrated by distributions of oscillatory shear index and relative residence time, non-significant stenosis (<75% area reduction) has the potential to induce atherosclerosis near the ostium of downstream side branch, while significant stenosis can promote atherosclerosis in its wake." @default.
- W2065647657 created "2016-06-24" @default.
- W2065647657 creator A5020888035 @default.
- W2065647657 creator A5023291436 @default.
- W2065647657 creator A5028692361 @default.
- W2065647657 creator A5059700119 @default.
- W2065647657 creator A5071334202 @default.
- W2065647657 creator A5071656030 @default.
- W2065647657 creator A5081782138 @default.
- W2065647657 date "2014-04-01" @default.
- W2065647657 modified "2023-10-16" @default.
- W2065647657 title "Numerical investigation of blood flow in three-dimensional porcine left anterior descending artery with various stenoses" @default.
- W2065647657 cites W1963578344 @default.
- W2065647657 cites W1970382876 @default.
- W2065647657 cites W1973326405 @default.
- W2065647657 cites W1976995398 @default.
- W2065647657 cites W1987540114 @default.
- W2065647657 cites W1988270137 @default.
- W2065647657 cites W1996139367 @default.
- W2065647657 cites W1997199500 @default.
- W2065647657 cites W2003342869 @default.
- W2065647657 cites W2022222905 @default.
- W2065647657 cites W2024697557 @default.
- W2065647657 cites W2029271476 @default.
- W2065647657 cites W2030553685 @default.
- W2065647657 cites W2043856203 @default.
- W2065647657 cites W2046322851 @default.
- W2065647657 cites W2049539003 @default.
- W2065647657 cites W2051648175 @default.
- W2065647657 cites W2052632466 @default.
- W2065647657 cites W2053420204 @default.
- W2065647657 cites W2057183214 @default.
- W2065647657 cites W2065591461 @default.
- W2065647657 cites W2067824277 @default.
- W2065647657 cites W2077647219 @default.
- W2065647657 cites W2083373724 @default.
- W2065647657 cites W2101337909 @default.
- W2065647657 cites W2103709258 @default.
- W2065647657 cites W2104078373 @default.
- W2065647657 cites W2105650496 @default.
- W2065647657 cites W2108449984 @default.
- W2065647657 cites W2118220877 @default.
- W2065647657 cites W2122199198 @default.
- W2065647657 cites W2122201881 @default.
- W2065647657 cites W2125674758 @default.
- W2065647657 cites W2130701170 @default.
- W2065647657 cites W2130744279 @default.
- W2065647657 cites W2134688511 @default.
- W2065647657 cites W2156083039 @default.
- W2065647657 cites W2166365959 @default.
- W2065647657 cites W2328852314 @default.
- W2065647657 cites W2599288929 @default.
- W2065647657 cites W3021842026 @default.
- W2065647657 cites W4297744615 @default.
- W2065647657 doi "https://doi.org/10.1016/j.compbiomed.2014.01.001" @default.
- W2065647657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24607680" @default.
- W2065647657 hasPublicationYear "2014" @default.
- W2065647657 type Work @default.
- W2065647657 sameAs 2065647657 @default.
- W2065647657 citedByCount "20" @default.
- W2065647657 countsByYear W20656476572015 @default.
- W2065647657 countsByYear W20656476572016 @default.
- W2065647657 countsByYear W20656476572017 @default.
- W2065647657 countsByYear W20656476572018 @default.
- W2065647657 countsByYear W20656476572019 @default.
- W2065647657 countsByYear W20656476572020 @default.
- W2065647657 countsByYear W20656476572021 @default.
- W2065647657 countsByYear W20656476572022 @default.
- W2065647657 countsByYear W20656476572023 @default.
- W2065647657 crossrefType "journal-article" @default.
- W2065647657 hasAuthorship W2065647657A5020888035 @default.
- W2065647657 hasAuthorship W2065647657A5023291436 @default.
- W2065647657 hasAuthorship W2065647657A5028692361 @default.
- W2065647657 hasAuthorship W2065647657A5059700119 @default.
- W2065647657 hasAuthorship W2065647657A5071334202 @default.
- W2065647657 hasAuthorship W2065647657A5071656030 @default.
- W2065647657 hasAuthorship W2065647657A5081782138 @default.
- W2065647657 hasConcept C126322002 @default.
- W2065647657 hasConcept C158846371 @default.
- W2065647657 hasConcept C164705383 @default.
- W2065647657 hasConcept C178853913 @default.
- W2065647657 hasConcept C18903297 @default.
- W2065647657 hasConcept C2776619873 @default.
- W2065647657 hasConcept C2776820930 @default.
- W2065647657 hasConcept C2778930955 @default.
- W2065647657 hasConcept C2780007028 @default.
- W2065647657 hasConcept C2781197403 @default.
- W2065647657 hasConcept C71924100 @default.
- W2065647657 hasConcept C86803240 @default.
- W2065647657 hasConceptScore W2065647657C126322002 @default.
- W2065647657 hasConceptScore W2065647657C158846371 @default.
- W2065647657 hasConceptScore W2065647657C164705383 @default.
- W2065647657 hasConceptScore W2065647657C178853913 @default.
- W2065647657 hasConceptScore W2065647657C18903297 @default.
- W2065647657 hasConceptScore W2065647657C2776619873 @default.
- W2065647657 hasConceptScore W2065647657C2776820930 @default.
- W2065647657 hasConceptScore W2065647657C2778930955 @default.
- W2065647657 hasConceptScore W2065647657C2780007028 @default.