Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065652078> ?p ?o ?g. }
- W2065652078 endingPage "7868" @default.
- W2065652078 startingPage "7864" @default.
- W2065652078 abstract "Differentiation induction in murine M1 leukemia cells by interleukin 6 (IL-6), leukemia inhibitory factor (LIF), and oncostatin M (OSM) is postulated to occur via a common receptor chain, gp130. In this study, growth factor-induced differentiation of M1 cells was accompanied by a late and persistent decrease in levels of mRNA and protein for a helix-loop-helix transcription factor, the SCL gene product. To evaluate whether reduced SCL expression was instrumental in monocyte differentiation, an SCL cDNA expression vector was introduced into M1 cells to obtain cell lines in which overexpression of SCL mRNA and protein was enforced. This resulted in a reduction in cells differentiating in response to LIF and OSM but not in response to IL-6. Scatchard analysis indicated that both parental and SCL-transfected cell lines exhibited similar receptor numbers and receptor affinities for LIF, OSM, and IL-6, suggesting that the differential responsiveness was not due to selective receptor down-modulation. Thus, these data implicate SCL in monocytic differentiation and provide evidence for differential receptor signaling pathways despite utilization of a common gp130 subunit by all three receptors." @default.
- W2065652078 created "2016-06-24" @default.
- W2065652078 creator A5033413968 @default.
- W2065652078 creator A5037049833 @default.
- W2065652078 creator A5057005677 @default.
- W2065652078 creator A5069357139 @default.
- W2065652078 creator A5072354499 @default.
- W2065652078 creator A5074341523 @default.
- W2065652078 creator A5075979227 @default.
- W2065652078 date "1993-08-15" @default.
- W2065652078 modified "2023-09-27" @default.
- W2065652078 title "The SCL gene product is regulated by and differentially regulates cytokine responses during myeloid leukemic cell differentiation." @default.
- W2065652078 cites W109291748 @default.
- W2065652078 cites W122007457 @default.
- W2065652078 cites W129878118 @default.
- W2065652078 cites W140106909 @default.
- W2065652078 cites W1502331175 @default.
- W2065652078 cites W1524614578 @default.
- W2065652078 cites W1575638464 @default.
- W2065652078 cites W1609632876 @default.
- W2065652078 cites W1677366327 @default.
- W2065652078 cites W1682711168 @default.
- W2065652078 cites W1750539994 @default.
- W2065652078 cites W1838164985 @default.
- W2065652078 cites W1852214165 @default.
- W2065652078 cites W1968814677 @default.
- W2065652078 cites W1972119462 @default.
- W2065652078 cites W1996548067 @default.
- W2065652078 cites W1997261857 @default.
- W2065652078 cites W2012895108 @default.
- W2065652078 cites W2017223857 @default.
- W2065652078 cites W2041566569 @default.
- W2065652078 cites W2056172754 @default.
- W2065652078 cites W2062734043 @default.
- W2065652078 cites W2068133110 @default.
- W2065652078 cites W2073894431 @default.
- W2065652078 cites W2074749955 @default.
- W2065652078 cites W2082670705 @default.
- W2065652078 cites W2085451664 @default.
- W2065652078 cites W2096971613 @default.
- W2065652078 cites W2097939870 @default.
- W2065652078 cites W2108490725 @default.
- W2065652078 cites W2119121495 @default.
- W2065652078 cites W2167671260 @default.
- W2065652078 cites W2168638691 @default.
- W2065652078 cites W2241970596 @default.
- W2065652078 cites W2263179554 @default.
- W2065652078 cites W2412864637 @default.
- W2065652078 cites W2413712552 @default.
- W2065652078 cites W2414627607 @default.
- W2065652078 cites W2418442192 @default.
- W2065652078 cites W2467916015 @default.
- W2065652078 cites W27140539 @default.
- W2065652078 cites W48388848 @default.
- W2065652078 doi "https://doi.org/10.1073/pnas.90.16.7864" @default.
- W2065652078 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/47243" @default.
- W2065652078 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8356096" @default.
- W2065652078 hasPublicationYear "1993" @default.
- W2065652078 type Work @default.
- W2065652078 sameAs 2065652078 @default.
- W2065652078 citedByCount "48" @default.
- W2065652078 countsByYear W20656520782013 @default.
- W2065652078 countsByYear W20656520782014 @default.
- W2065652078 countsByYear W20656520782016 @default.
- W2065652078 countsByYear W20656520782021 @default.
- W2065652078 crossrefType "journal-article" @default.
- W2065652078 hasAuthorship W2065652078A5033413968 @default.
- W2065652078 hasAuthorship W2065652078A5037049833 @default.
- W2065652078 hasAuthorship W2065652078A5057005677 @default.
- W2065652078 hasAuthorship W2065652078A5069357139 @default.
- W2065652078 hasAuthorship W2065652078A5072354499 @default.
- W2065652078 hasAuthorship W2065652078A5074341523 @default.
- W2065652078 hasAuthorship W2065652078A5075979227 @default.
- W2065652078 hasBestOaLocation W20656520781 @default.
- W2065652078 hasConcept C104317684 @default.
- W2065652078 hasConcept C11988809 @default.
- W2065652078 hasConcept C126037660 @default.
- W2065652078 hasConcept C148738053 @default.
- W2065652078 hasConcept C153911025 @default.
- W2065652078 hasConcept C170493617 @default.
- W2065652078 hasConcept C203014093 @default.
- W2065652078 hasConcept C27284151 @default.
- W2065652078 hasConcept C2775855021 @default.
- W2065652078 hasConcept C2777667943 @default.
- W2065652078 hasConcept C2778690821 @default.
- W2065652078 hasConcept C2778923194 @default.
- W2065652078 hasConcept C54355233 @default.
- W2065652078 hasConcept C62478195 @default.
- W2065652078 hasConcept C81885089 @default.
- W2065652078 hasConcept C86803240 @default.
- W2065652078 hasConcept C95444343 @default.
- W2065652078 hasConceptScore W2065652078C104317684 @default.
- W2065652078 hasConceptScore W2065652078C11988809 @default.
- W2065652078 hasConceptScore W2065652078C126037660 @default.
- W2065652078 hasConceptScore W2065652078C148738053 @default.
- W2065652078 hasConceptScore W2065652078C153911025 @default.
- W2065652078 hasConceptScore W2065652078C170493617 @default.
- W2065652078 hasConceptScore W2065652078C203014093 @default.