FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065653458> ?p ?o ?g. }

• W2065653458 endingPage "763" @default.
• W2065653458 startingPage "758" @default.
• W2065653458 abstract "Clonidine is often used as a sedative in critically ill children, but its effectiveness has not been evaluated in a large, rigorous randomized controlled trial. Our objectives in this pilot trial were to assess the feasibility of a larger trial with respect to (1) effective screening, (2) recruitment, (3) timely drug administration, and (4) protocol adherence. This is a randomized, blinded, placebo-controlled pilot trial. Mechanically ventilated children received enteral clonidine 5 μg/kg or placebo every 6 hours; additional sedatives were at the discretion of attending physicians. We enrolled 50 children. The median interquartile range (IQR) age was 2.5 (0.7-5.2) years, and Pediatric Risk of Mortality score on pediatric intensive care unit admission was 12 (8-15). In terms of feasibility outcomes, 90 (87%) of 104 eligible patients were approached for consent, and on average, 1.7 children were enrolled per month. Thirty-five (70%) were enrolled within 1 day of becoming eligible (mean, 1.2 days). Thereafter, 94% of doses were administered by protocol. Clinical outcomes and adverse effects were not significantly different between the groups. This pilot trial demonstrated feasibility of a larger randomized controlled trial. Some important challenges emerged, allowing refinement of the study protocol and enrolment estimates. We recommend that future trials capitalize on the experience gained and use these results to design a larger trial focusing on clinically important outcomes." @default.
• W2065653458 created "2016-06-24" @default.
• W2065653458 creator A5023037123 @default.
• W2065653458 creator A5030817657 @default.
• W2065653458 creator A5035163396 @default.
• W2065653458 creator A5050946779 @default.
• W2065653458 creator A5059393102 @default.
• W2065653458 creator A5084752934 @default.
• W2065653458 creator A5090561962 @default.
• W2065653458 date "2014-10-01" @default.
• W2065653458 modified "2023-09-27" @default.
• W2065653458 title "Clonidine in the sedation of mechanically ventilated children: A pilot randomized trial" @default.
• W2065653458 cites W1968265383 @default.
• W2065653458 cites W1969334283 @default.
• W2065653458 cites W1978118340 @default.
• W2065653458 cites W1992423924 @default.
• W2065653458 cites W1993670218 @default.
• W2065653458 cites W1994075182 @default.
• W2065653458 cites W2000935621 @default.
• W2065653458 cites W2004473899 @default.
• W2065653458 cites W2017187056 @default.
• W2065653458 cites W2055341118 @default.
• W2065653458 cites W2070544236 @default.
• W2065653458 cites W2071735347 @default.
• W2065653458 cites W2084445380 @default.
• W2065653458 cites W2133314444 @default.
• W2065653458 cites W2138013284 @default.
• W2065653458 cites W2143504904 @default.
• W2065653458 cites W2146876425 @default.
• W2065653458 cites W2148393693 @default.
• W2065653458 cites W2150988464 @default.
• W2065653458 cites W2156957408 @default.
• W2065653458 cites W2161177126 @default.
• W2065653458 cites W2170182466 @default.
• W2065653458 doi "https://doi.org/10.1016/j.jcrc.2014.05.029" @default.
• W2065653458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25015006" @default.
• W2065653458 hasPublicationYear "2014" @default.
• W2065653458 type Work @default.
• W2065653458 sameAs 2065653458 @default.
• W2065653458 citedByCount "27" @default.
• W2065653458 countsByYear W20656534582014 @default.
• W2065653458 countsByYear W20656534582015 @default.
• W2065653458 countsByYear W20656534582016 @default.
• W2065653458 countsByYear W20656534582017 @default.
• W2065653458 countsByYear W20656534582018 @default.
• W2065653458 countsByYear W20656534582019 @default.
• W2065653458 countsByYear W20656534582020 @default.
• W2065653458 countsByYear W20656534582021 @default.
• W2065653458 countsByYear W20656534582022 @default.
• W2065653458 crossrefType "journal-article" @default.
• W2065653458 hasAuthorship W2065653458A5023037123 @default.
• W2065653458 hasAuthorship W2065653458A5030817657 @default.
• W2065653458 hasAuthorship W2065653458A5035163396 @default.
• W2065653458 hasAuthorship W2065653458A5050946779 @default.
• W2065653458 hasAuthorship W2065653458A5059393102 @default.
• W2065653458 hasAuthorship W2065653458A5084752934 @default.
• W2065653458 hasAuthorship W2065653458A5090561962 @default.
• W2065653458 hasConcept C119060515 @default.
• W2065653458 hasConcept C126322002 @default.
• W2065653458 hasConcept C141071460 @default.
• W2065653458 hasConcept C142724271 @default.
• W2065653458 hasConcept C168563851 @default.
• W2065653458 hasConcept C187212893 @default.
• W2065653458 hasConcept C194828623 @default.
• W2065653458 hasConcept C197934379 @default.
• W2065653458 hasConcept C204787440 @default.
• W2065653458 hasConcept C27081682 @default.
• W2065653458 hasConcept C2776814716 @default.
• W2065653458 hasConcept C2777602617 @default.
• W2065653458 hasConcept C2778399450 @default.
• W2065653458 hasConcept C2780385302 @default.
• W2065653458 hasConcept C42219234 @default.
• W2065653458 hasConcept C535046627 @default.
• W2065653458 hasConcept C71924100 @default.
• W2065653458 hasConceptScore W2065653458C119060515 @default.
• W2065653458 hasConceptScore W2065653458C126322002 @default.
• W2065653458 hasConceptScore W2065653458C141071460 @default.
• W2065653458 hasConceptScore W2065653458C142724271 @default.
• W2065653458 hasConceptScore W2065653458C168563851 @default.
• W2065653458 hasConceptScore W2065653458C187212893 @default.
• W2065653458 hasConceptScore W2065653458C194828623 @default.
• W2065653458 hasConceptScore W2065653458C197934379 @default.
• W2065653458 hasConceptScore W2065653458C204787440 @default.
• W2065653458 hasConceptScore W2065653458C27081682 @default.
• W2065653458 hasConceptScore W2065653458C2776814716 @default.
• W2065653458 hasConceptScore W2065653458C2777602617 @default.
• W2065653458 hasConceptScore W2065653458C2778399450 @default.
• W2065653458 hasConceptScore W2065653458C2780385302 @default.
• W2065653458 hasConceptScore W2065653458C42219234 @default.
• W2065653458 hasConceptScore W2065653458C535046627 @default.
• W2065653458 hasConceptScore W2065653458C71924100 @default.
• W2065653458 hasIssue "5" @default.
• W2065653458 hasLocation W20656534581 @default.
• W2065653458 hasLocation W20656534582 @default.
• W2065653458 hasOpenAccess W2065653458 @default.
• W2065653458 hasPrimaryLocation W20656534581 @default.
• W2065653458 hasRelatedWork W1894855081 @default.
• W2065653458 hasRelatedWork W199554565 @default.

• next