FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065659741> ?p ?o ?g. }

• W2065659741 endingPage "166" @default.
• W2065659741 startingPage "166" @default.
• W2065659741 abstract "In the early 1970s, Ken Wan-en published an epic challenge to all th~se who maintained that the declines in age-specific prevalence and intensity of schistosomiasis seen in endemic areas were la~,,ely due to acquired immunity, In his article ~ entitled 'Regulation of the prevalence and intensity of schistosomiasis in man: immunology or ecology?' Ken ar~gued that it was intrinsic biological characteristics of the schistosomes together with behavioural factors such as age-related declines in water contact, rather than acquired immunity, that generated the typical convex curves. Twenty years on, following long ,nd detailed studies in Kenya, The Gambia ard Brazil, it appeared that Ken's question had been conclusively answered: obviously, water contact was an important determinant of schistosome infection, but acquired immunity was a major factor in generating the observed age-specific patterns of infection in endemic areas. But now Bruno Gryseels 2 has, through his fascinating observations made in newly emergent loci, once again thrown the question of the importance of human immunity wide open, though this time the subtext of the question posed is in effect: 'Immunity or puberty?' Probably this question can only be settled by continuing study of these emergent foci of human schistosomiasis, but we should not forget ti t animals too get schistosomiasis, and that we can learn a lot from 'comparative medicine' studies on livestock infected with their own specie: of sct~istosomes and work on indigenous species of monkeys infecled with human schistosome species. Fifteen years ago we reported that Schistosoma bovis (a member of the S. haematobium species group) in the natural bovine host does, like the human schistosome species, show declines in age- specific prevalence and intensity of infection in endemic areasL Experimental challenge infection of putatively immune cattle with age-matched controls confirmed that these cattle were indeed clinically highly resistant to challenge, whereas the age-matched controls were severely affected 4. Parasitologically, we found that this resistance to the effects of challenge infection was mediated mainly by suppression of worm fecundity, rather than prevention of challenge worm maturation. Indeed, cattle with high levels of clinically protective immunity nevertheless harboured large numbers of adult worms, though these prociuced few eggs. Evidence that this suppression was likely to be immunologically induced came from the demonstration that 'suppressed' worms resumed hig~l levels of egg production when surgically t~-ansplanted to naive, age-matched controls ~ and that fecundity-suppressive effects could be passively transfen-ed with serL, m 6. Recently, Jozef Vercruysse and coileagues have reported that cattle also naturally develop a similar type of acquired ~mmunity to S. mattheei, another member of the S. haemutobium species group:'. I think it likely that a similar type of naturally acquired immunity may occur in human schistosomiasis, particularly since, as was" @default.
• W2065659741 created "2016-06-24" @default.
• W2065659741 creator A5061391958 @default.
• W2065659741 date "1996-04-01" @default.
• W2065659741 modified "2023-10-17" @default.
• W2065659741 title "Immunity to schistosomes in humans and other animals" @default.
• W2065659741 cites W1466020826 @default.
• W2065659741 cites W1897413639 @default.
• W2065659741 cites W1964510112 @default.
• W2065659741 cites W1983498744 @default.
• W2065659741 cites W1995974557 @default.
• W2065659741 cites W2011520071 @default.
• W2065659741 cites W2056945393 @default.
• W2065659741 cites W2467878593 @default.
• W2065659741 cites W338229270 @default.
• W2065659741 doi "https://doi.org/10.1016/0169-4758(96)80810-6" @default.
• W2065659741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15275232" @default.
• W2065659741 hasPublicationYear "1996" @default.
• W2065659741 type Work @default.
• W2065659741 sameAs 2065659741 @default.
• W2065659741 citedByCount "1" @default.
• W2065659741 crossrefType "journal-article" @default.
• W2065659741 hasAuthorship W2065659741A5061391958 @default.
• W2065659741 hasConcept C159047783 @default.
• W2065659741 hasConcept C203014093 @default.
• W2065659741 hasConcept C2779341262 @default.
• W2065659741 hasConcept C71924100 @default.
• W2065659741 hasConcept C86803240 @default.
• W2065659741 hasConcept C8891405 @default.
• W2065659741 hasConceptScore W2065659741C159047783 @default.
• W2065659741 hasConceptScore W2065659741C203014093 @default.
• W2065659741 hasConceptScore W2065659741C2779341262 @default.
• W2065659741 hasConceptScore W2065659741C71924100 @default.
• W2065659741 hasConceptScore W2065659741C86803240 @default.
• W2065659741 hasConceptScore W2065659741C8891405 @default.
• W2065659741 hasIssue "4" @default.
• W2065659741 hasLocation W20656597411 @default.
• W2065659741 hasLocation W20656597412 @default.
• W2065659741 hasOpenAccess W2065659741 @default.
• W2065659741 hasPrimaryLocation W20656597411 @default.
• W2065659741 hasRelatedWork W1702322095 @default.
• W2065659741 hasRelatedWork W1865764402 @default.
• W2065659741 hasRelatedWork W1975114493 @default.
• W2065659741 hasRelatedWork W2055735866 @default.
• W2065659741 hasRelatedWork W2089697291 @default.
• W2065659741 hasRelatedWork W2093576198 @default.
• W2065659741 hasRelatedWork W2118087741 @default.
• W2065659741 hasRelatedWork W2178599865 @default.
• W2065659741 hasRelatedWork W2283522479 @default.
• W2065659741 hasRelatedWork W3029386773 @default.
• W2065659741 hasVolume "12" @default.
• W2065659741 isParatext "false" @default.
• W2065659741 isRetracted "false" @default.
• W2065659741 magId "2065659741" @default.
• W2065659741 workType "article" @default.