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- W2065661880 abstract "Summary: One-hundred twenty-five serum samples from 82 patients with juvenile rheumatoid arthritis (JRA) were studied for the presence of hidden rheumatoid factor (RF) in an effort to find a better serologic marker to define JRA. Hidden 19S IgM RF was detected by means of a hemolytic assay utilizing the IgM-containing fraction of serum. The IgM fraction was obtained after acid separation of serum on a Sephadex G-200 column. Hidden 19S IgM RF was present in 68% of patients with seronegative JRA with a mean titer of 1:63. The mean titer for the polyarticular JRA group was 1:83, for the pauciarticular JRA group, it was 1:32, and for the systemic type-onset JRA patients, it was 1:32. When disease was active, the mean titer for all JRA patients was 1:108, for the active polyarticular JRA group it was 1:119, for the active pauciarticular JRA, it was 1:97, and for the active systemic JRA patients, it was 1:64. All values were significant at the P ≤ 0.001 when compared to disease and normal controls. The hemolytic assay for RF on the IgM-containing fraction of serum thus enhances the serologic capabilities of defining JRA. Speculation: These studies showing the correlation of disease activity and the presence of hidden rheumatoid factor will aid in evaluating and following disease activity in juvenile rheumatoid arthritis." @default.
- W2065661880 created "2016-06-24" @default.
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- W2065661880 date "1980-10-01" @default.
- W2065661880 modified "2023-09-26" @default.
- W2065661880 title "Hidden 19S IgM Rheumatoid Factor in Juvenile Rheumatoid Arthritis" @default.
- W2065661880 doi "https://doi.org/10.1203/00006450-198010000-00010" @default.
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