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• W2065670710 abstract "The Ca2+ ionophore A23187 (0.2–5 μM) stimulates the phosphorylation of the substrates of protein kinase C (40,000 dalton protein) and myosin light chain kinase (20,000 dalton protein) in the presence or absence of cyclooxygenase inhibitors. In the presence of cyclooxygenase inhibitors or millimolar Ca2+ there is no stimulation of phospholipase C by A23187. Fingerprints of the 32P-labeled 40,000 dalton protein isolated from platelets that have been stimulated with A23187, thrombin, phorbol 12, 13-dibutyrate and 1,2-didecanoylglycerol were identical. Higher concentrations of A23187 (1–5 μM) induced the loss of polyphosphoinositides through phosphomonoesterase activity." @default.
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• W2065670710 date "1986-08-01" @default.
• W2065670710 modified "2023-09-26" @default.
• W2065670710 title "Ionophore A23187 stimulates phosphorylation of the 40, 000dalton protein in human platelets without phospholipase C activation" @default.
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• W2065670710 doi "https://doi.org/10.1016/0024-3205(86)90024-x" @default.
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