FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065672011> ?p ?o ?g. }

• W2065672011 endingPage "43" @default.
• W2065672011 startingPage "35" @default.
• W2065672011 abstract "Liver fibrosis represents the final common pathway of virtually all types of chronic liver diseases, and it has been a major public health concern. Many genes have been demonstrated to be involved in the pathogenesis of liver fibrosis, while the mechanisms underlying gene regulation still needs further research. On the other hand, hepatic stellate cells (HSCs) are quiescent cells in the perisinusoidal space in liver. HSCs facilitate hepatocytes interactions via releasing soluble inflammatory factors and producing extracellular matrix. HSCs can be activated in response to liver injury, and they differentiate to myofibroblasts, which greatly contribute to the fibrogenesis process. Various epigenetic procedures, including DNA methylation, histone modification and formation of particular chromatin structure, play crucial roles in the gene transcriptional expression in HSCs, regulating various vital processes. For instance, epigenetic modulation on the peroxisome proliferator-activated receptor gamma (PPAR-γ) gene promoter accounts for HSC differentiation through interacting pathways. Aberrant expression of a series of histones and chemokines in activated HSCs can aggravate inflammation and oxidative stress, which in turn promotes differentiation of HSCs to myofibroblasts and enhances the whole fibrogenesis process. Degradation of extracellular matrix is also regulated through epigenetic modulation on matrix associated enzymes. Moreover, fibrosis-related epigenetic modifications in the parental generation may be inherited to their offspring. In this review, we firstly summarize the vital epigenetic modifications of fibrosis-related genes in HSCs, and highlight specific nucleic acid sequences and structures in gene promoters as important action sites, which may provide indicators for liver fibrosis diagnosis in the future." @default.
• W2065672011 created "2016-06-24" @default.
• W2065672011 creator A5004669303 @default.
• W2065672011 creator A5006168613 @default.
• W2065672011 creator A5034071178 @default.
• W2065672011 creator A5050237368 @default.
• W2065672011 creator A5090979290 @default.
• W2065672011 date "2013-01-01" @default.
• W2065672011 modified "2023-10-17" @default.
• W2065672011 title "Epigenetic Modifications in Hepatic Stellate Cells Contribute to Liver Fibrosis" @default.
• W2065672011 cites W1522996100 @default.
• W2065672011 cites W1564491750 @default.
• W2065672011 cites W1831059025 @default.
• W2065672011 cites W1886848895 @default.
• W2065672011 cites W1888687424 @default.
• W2065672011 cites W1964368260 @default.
• W2065672011 cites W1974140734 @default.
• W2065672011 cites W1974205834 @default.
• W2065672011 cites W1974503699 @default.
• W2065672011 cites W1979372049 @default.
• W2065672011 cites W1981101682 @default.
• W2065672011 cites W1982160368 @default.
• W2065672011 cites W1991161256 @default.
• W2065672011 cites W1996254954 @default.
• W2065672011 cites W2007769219 @default.
• W2065672011 cites W2009036920 @default.
• W2065672011 cites W2017829956 @default.
• W2065672011 cites W2022372415 @default.
• W2065672011 cites W2025657436 @default.
• W2065672011 cites W2028273847 @default.
• W2065672011 cites W2031002674 @default.
• W2065672011 cites W2035774221 @default.
• W2065672011 cites W2038879992 @default.
• W2065672011 cites W2042494320 @default.
• W2065672011 cites W2046100841 @default.
• W2065672011 cites W2046157927 @default.
• W2065672011 cites W2055125978 @default.
• W2065672011 cites W2071116774 @default.
• W2065672011 cites W2077427931 @default.
• W2065672011 cites W2085604012 @default.
• W2065672011 cites W2086822322 @default.
• W2065672011 cites W2089076289 @default.
• W2065672011 cites W2102099816 @default.
• W2065672011 cites W2111288662 @default.
• W2065672011 cites W2138966960 @default.
• W2065672011 cites W2142988890 @default.
• W2065672011 cites W2147963611 @default.
• W2065672011 cites W2151898526 @default.
• W2065672011 cites W2164247688 @default.
• W2065672011 cites W2166038147 @default.
• W2065672011 cites W2314773092 @default.
• W2065672011 cites W2604337567 @default.
• W2065672011 doi "https://doi.org/10.1620/tjem.229.35" @default.
• W2065672011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23238615" @default.
• W2065672011 hasPublicationYear "2013" @default.
• W2065672011 type Work @default.
• W2065672011 sameAs 2065672011 @default.
• W2065672011 citedByCount "28" @default.
• W2065672011 countsByYear W20656720112013 @default.
• W2065672011 countsByYear W20656720112014 @default.
• W2065672011 countsByYear W20656720112015 @default.
• W2065672011 countsByYear W20656720112016 @default.
• W2065672011 countsByYear W20656720112017 @default.
• W2065672011 countsByYear W20656720112018 @default.
• W2065672011 countsByYear W20656720112019 @default.
• W2065672011 countsByYear W20656720112020 @default.
• W2065672011 countsByYear W20656720112021 @default.
• W2065672011 crossrefType "journal-article" @default.
• W2065672011 hasAuthorship W2065672011A5004669303 @default.
• W2065672011 hasAuthorship W2065672011A5006168613 @default.
• W2065672011 hasAuthorship W2065672011A5034071178 @default.
• W2065672011 hasAuthorship W2065672011A5050237368 @default.
• W2065672011 hasAuthorship W2065672011A5090979290 @default.
• W2065672011 hasBestOaLocation W20656720111 @default.
• W2065672011 hasConcept C104317684 @default.
• W2065672011 hasConcept C134018914 @default.
• W2065672011 hasConcept C142724271 @default.
• W2065672011 hasConcept C150194340 @default.
• W2065672011 hasConcept C167227067 @default.
• W2065672011 hasConcept C176891718 @default.
• W2065672011 hasConcept C189165786 @default.
• W2065672011 hasConcept C190727270 @default.
• W2065672011 hasConcept C2780559512 @default.
• W2065672011 hasConcept C2993667909 @default.
• W2065672011 hasConcept C41091548 @default.
• W2065672011 hasConcept C502942594 @default.
• W2065672011 hasConcept C54355233 @default.
• W2065672011 hasConcept C63016187 @default.
• W2065672011 hasConcept C64927066 @default.
• W2065672011 hasConcept C71924100 @default.
• W2065672011 hasConcept C83640560 @default.
• W2065672011 hasConcept C86803240 @default.
• W2065672011 hasConcept C95444343 @default.
• W2065672011 hasConceptScore W2065672011C104317684 @default.
• W2065672011 hasConceptScore W2065672011C134018914 @default.
• W2065672011 hasConceptScore W2065672011C142724271 @default.
• W2065672011 hasConceptScore W2065672011C150194340 @default.
• W2065672011 hasConceptScore W2065672011C167227067 @default.

• next