FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065673896> ?p ?o ?g. }

• W2065673896 endingPage "680" @default.
• W2065673896 startingPage "669" @default.
• W2065673896 abstract "Nm23-H1/NDPK-A, a tumour metastasis suppressor, is a multifunctional housekeeping enzyme with nucleoside diphos­phate kinase activity. Hexameric Nm23-H1 is required for suppression of tumour metastasis and it is dissociated into dimers under oxidative conditions. Here, the crystal structure of oxidized Nm23-H1 is presented. It reveals the formation of an intramolecular disulfide bond between Cys4 and Cys145 that triggers a large conformational change that destabilizes the hexameric state. The dependence of the dissociation dynamics on the H2O2 concentration was determined using hydrogen/deuterium-exchange experiments. The quaternary conformational change provides a suitable environment for the oxidation of Cys109 to sulfonic acid, as demonstrated by peptide sequencing using nanoUPLC-ESI-q-TOF tandem MS. From these and other data, it is proposed that the molecular and cellular functions of Nm23-H1 are regulated by a series of oxidative modifications coupled to its oligomeric states and that the modified cysteines are resolvable by NADPH-dependent reduction systems. These findings broaden the understanding of the complicated enzyme-regulatory mechanisms that operate under oxidative conditions." @default.
• W2065673896 created "2016-06-24" @default.
• W2065673896 creator A5012245094 @default.
• W2065673896 creator A5050139076 @default.
• W2065673896 creator A5068775765 @default.
• W2065673896 creator A5070875054 @default.
• W2065673896 creator A5079735717 @default.
• W2065673896 date "2013-03-14" @default.
• W2065673896 modified "2023-09-27" @default.
• W2065673896 title "Structure of Nm23-H1 under oxidative conditions" @default.
• W2065673896 cites W1500770275 @default.
• W2065673896 cites W1536252471 @default.
• W2065673896 cites W173685290 @default.
• W2065673896 cites W1827501265 @default.
• W2065673896 cites W1968560247 @default.
• W2065673896 cites W1978105472 @default.
• W2065673896 cites W1979293200 @default.
• W2065673896 cites W1982086440 @default.
• W2065673896 cites W1986191025 @default.
• W2065673896 cites W1995017064 @default.
• W2065673896 cites W2000220058 @default.
• W2065673896 cites W2004671988 @default.
• W2065673896 cites W2005652749 @default.
• W2065673896 cites W2008313628 @default.
• W2065673896 cites W2011516706 @default.
• W2065673896 cites W2011683954 @default.
• W2065673896 cites W2012013653 @default.
• W2065673896 cites W2021769399 @default.
• W2065673896 cites W2023042488 @default.
• W2065673896 cites W2026225426 @default.
• W2065673896 cites W2026397465 @default.
• W2065673896 cites W2029900321 @default.
• W2065673896 cites W2030993532 @default.
• W2065673896 cites W2036071967 @default.
• W2065673896 cites W2036734265 @default.
• W2065673896 cites W2037007932 @default.
• W2065673896 cites W2039321218 @default.
• W2065673896 cites W2040956342 @default.
• W2065673896 cites W2050316512 @default.
• W2065673896 cites W2052386120 @default.
• W2065673896 cites W2052464531 @default.
• W2065673896 cites W2057477598 @default.
• W2065673896 cites W2058292371 @default.
• W2065673896 cites W2061647812 @default.
• W2065673896 cites W2068777108 @default.
• W2065673896 cites W2069236757 @default.
• W2065673896 cites W2072960304 @default.
• W2065673896 cites W2075939897 @default.
• W2065673896 cites W2076367848 @default.
• W2065673896 cites W2076615266 @default.
• W2065673896 cites W2076985939 @default.
• W2065673896 cites W2082625380 @default.
• W2065673896 cites W2086132105 @default.
• W2065673896 cites W2091802247 @default.
• W2065673896 cites W2093069373 @default.
• W2065673896 cites W2107506448 @default.
• W2065673896 cites W2107919301 @default.
• W2065673896 cites W2108921801 @default.
• W2065673896 cites W2115318272 @default.
• W2065673896 cites W2120772351 @default.
• W2065673896 cites W2124026197 @default.
• W2065673896 cites W2136041406 @default.
• W2065673896 cites W2138761356 @default.
• W2065673896 cites W2144504775 @default.
• W2065673896 cites W2147338798 @default.
• W2065673896 cites W2154197653 @default.
• W2065673896 cites W2158496331 @default.
• W2065673896 cites W2167168684 @default.
• W2065673896 cites W2180229411 @default.
• W2065673896 cites W4255751396 @default.
• W2065673896 doi "https://doi.org/10.1107/s0907444913001194" @default.
• W2065673896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23519676" @default.
• W2065673896 hasPublicationYear "2013" @default.
• W2065673896 type Work @default.
• W2065673896 sameAs 2065673896 @default.
• W2065673896 citedByCount "21" @default.
• W2065673896 countsByYear W20656738962014 @default.
• W2065673896 countsByYear W20656738962015 @default.
• W2065673896 countsByYear W20656738962016 @default.
• W2065673896 countsByYear W20656738962017 @default.
• W2065673896 countsByYear W20656738962018 @default.
• W2065673896 countsByYear W20656738962019 @default.
• W2065673896 countsByYear W20656738962020 @default.
• W2065673896 countsByYear W20656738962021 @default.
• W2065673896 countsByYear W20656738962023 @default.
• W2065673896 crossrefType "journal-article" @default.
• W2065673896 hasAuthorship W2065673896A5012245094 @default.
• W2065673896 hasAuthorship W2065673896A5050139076 @default.
• W2065673896 hasAuthorship W2065673896A5068775765 @default.
• W2065673896 hasAuthorship W2065673896A5070875054 @default.
• W2065673896 hasAuthorship W2065673896A5079735717 @default.
• W2065673896 hasConcept C112887158 @default.
• W2065673896 hasConcept C12554922 @default.
• W2065673896 hasConcept C178790620 @default.
• W2065673896 hasConcept C181199279 @default.
• W2065673896 hasConcept C185592680 @default.
• W2065673896 hasConcept C2777339483 @default.
• W2065673896 hasConcept C2779281246 @default.

• next