FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065674713> ?p ?o ?g. }

• W2065674713 endingPage "205" @default.
• W2065674713 startingPage "199" @default.
• W2065674713 abstract "The thiopurine drugs, azathioprine (AZA) and 6-mercaptopurine, are established in the treatment of inflammatory bowel diseases (IBD). Polymorphisms in thiopurine S-methyltransferase (TPMT) gene have been associated with adverse drug reactions (ADRs) to AZA.The aim of this study was to evaluate TPMT polymorphisms and AZA-related toxicity in a Slovak cohort of 220 IBD patients treated with AZA. In every patient, the dose and duration of AZA therapy, concomitant 5-aminosalicylate (5-ASA) medication, frequency, type, time to onset, dose of ADR and concomitant 5-ASA at the onset of ADR were recorded. Each patient was also genotyped for the presence of variant TPMT alleles (*2,*3A,*3B,*3C). Frequency, type and circumstances of ADRs were compared according to TPMT status.Of the 220 patients, 205 (93.2 %) were wild-type (TPMT*1/*1), one (0.5%) carried a TPMT*1/*3C allele, 13 (5.9 %) carried TPMT *1/*3A allele and one was homozygous for TMPT *3A allele. No TPMT *2 mutation was found. The incidence of adverse drug reactions was 62/205 (30.2 %) in the wild-type group as compared to 13/15 (86.7 %) in the TPMT mutation group, p=2.10-5. Leukopenia (WBC< 3.0*10^9/L) occurred in 21/205 (10.2 %) patients with wild type TPMT versus 11/15 (73.3 %) patients with TPMT mutations, p=0.000001. There was no significant difference between TMPT groups in gastrointestinal or other ADRs. No impact of 5-ASA on the incidence and severity of AZA adverse drug reactions was observed.The incidence of leukopenia in TPMT mutant patients was significantly higher and more severe as compared to TPMT wild type patients. We observed no impact of concomitant 5-ASA therapy on AZA induced toxicity (Tab. 4, Fig. 2, Ref. 37)." @default.
• W2065674713 created "2016-06-24" @default.
• W2065674713 creator A5011621601 @default.
• W2065674713 creator A5020470011 @default.
• W2065674713 creator A5023696038 @default.
• W2065674713 creator A5026972025 @default.
• W2065674713 creator A5027540270 @default.
• W2065674713 creator A5035634910 @default.
• W2065674713 creator A5044287183 @default.
• W2065674713 creator A5049324533 @default.
• W2065674713 creator A5054892704 @default.
• W2065674713 creator A5055182886 @default.
• W2065674713 creator A5064189444 @default.
• W2065674713 creator A5064401331 @default.
• W2065674713 creator A5073533050 @default.
• W2065674713 creator A5081928105 @default.
• W2065674713 date "2013-01-01" @default.
• W2065674713 modified "2023-10-01" @default.
• W2065674713 title "The impact of thiopurine-S-methyltransferase genotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases" @default.
• W2065674713 cites W1932835791 @default.
• W2065674713 cites W1978270674 @default.
• W2065674713 cites W1998888490 @default.
• W2065674713 cites W1999416574 @default.
• W2065674713 cites W2002298808 @default.
• W2065674713 cites W2012296574 @default.
• W2065674713 cites W2014389034 @default.
• W2065674713 cites W2024293518 @default.
• W2065674713 cites W2027947307 @default.
• W2065674713 cites W2029841402 @default.
• W2065674713 cites W2033674020 @default.
• W2065674713 cites W2034809256 @default.
• W2065674713 cites W2037707239 @default.
• W2065674713 cites W2038834175 @default.
• W2065674713 cites W2040894582 @default.
• W2065674713 cites W2043258441 @default.
• W2065674713 cites W2045691074 @default.
• W2065674713 cites W2057050126 @default.
• W2065674713 cites W2065350405 @default.
• W2065674713 cites W2082290344 @default.
• W2065674713 cites W2094758207 @default.
• W2065674713 cites W2101604689 @default.
• W2065674713 cites W2104784902 @default.
• W2065674713 cites W2108106767 @default.
• W2065674713 cites W2117657336 @default.
• W2065674713 cites W2127788790 @default.
• W2065674713 cites W2135958206 @default.
• W2065674713 cites W2136628679 @default.
• W2065674713 cites W2136857800 @default.
• W2065674713 cites W2156276514 @default.
• W2065674713 doi "https://doi.org/10.4149/bll_2013_042" @default.
• W2065674713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23514552" @default.
• W2065674713 hasPublicationYear "2013" @default.
• W2065674713 type Work @default.
• W2065674713 sameAs 2065674713 @default.
• W2065674713 citedByCount "2" @default.
• W2065674713 countsByYear W20656747132015 @default.
• W2065674713 countsByYear W20656747132021 @default.
• W2065674713 crossrefType "journal-article" @default.
• W2065674713 hasAuthorship W2065674713A5011621601 @default.
• W2065674713 hasAuthorship W2065674713A5020470011 @default.
• W2065674713 hasAuthorship W2065674713A5023696038 @default.
• W2065674713 hasAuthorship W2065674713A5026972025 @default.
• W2065674713 hasAuthorship W2065674713A5027540270 @default.
• W2065674713 hasAuthorship W2065674713A5035634910 @default.
• W2065674713 hasAuthorship W2065674713A5044287183 @default.
• W2065674713 hasAuthorship W2065674713A5049324533 @default.
• W2065674713 hasAuthorship W2065674713A5054892704 @default.
• W2065674713 hasAuthorship W2065674713A5055182886 @default.
• W2065674713 hasAuthorship W2065674713A5064189444 @default.
• W2065674713 hasAuthorship W2065674713A5064401331 @default.
• W2065674713 hasAuthorship W2065674713A5073533050 @default.
• W2065674713 hasAuthorship W2065674713A5081928105 @default.
• W2065674713 hasBestOaLocation W20656747131 @default.
• W2065674713 hasConcept C104317684 @default.
• W2065674713 hasConcept C120665830 @default.
• W2065674713 hasConcept C121332964 @default.
• W2065674713 hasConcept C126322002 @default.
• W2065674713 hasConcept C135763542 @default.
• W2065674713 hasConcept C197934379 @default.
• W2065674713 hasConcept C2776760755 @default.
• W2065674713 hasConcept C2779134260 @default.
• W2065674713 hasConcept C2779384505 @default.
• W2065674713 hasConcept C2780035454 @default.
• W2065674713 hasConcept C2780542314 @default.
• W2065674713 hasConcept C2780873365 @default.
• W2065674713 hasConcept C29730261 @default.
• W2065674713 hasConcept C37463918 @default.
• W2065674713 hasConcept C54355233 @default.
• W2065674713 hasConcept C55775858 @default.
• W2065674713 hasConcept C61511704 @default.
• W2065674713 hasConcept C70917649 @default.
• W2065674713 hasConcept C71924100 @default.
• W2065674713 hasConcept C86803240 @default.
• W2065674713 hasConcept C90924648 @default.
• W2065674713 hasConcept C98274493 @default.
• W2065674713 hasConceptScore W2065674713C104317684 @default.
• W2065674713 hasConceptScore W2065674713C120665830 @default.
• W2065674713 hasConceptScore W2065674713C121332964 @default.

• next