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- W2065683049 endingPage "299" @default.
- W2065683049 startingPage "289" @default.
- W2065683049 abstract "The metabolic syndrome has reached pandemic level worldwide, and evidence is that estradiol plays a key role in its development. The discovery of the second estrogen receptor, ERβ, in tissues previously not considered targets of estradiol was a breakthrough in endocrinology. In the present review, we discuss how the presence of ERβ and the previously described ERα in tissues involved in glucose and lipid homeostasis (brain, skeletal muscle, adipose tissue, pancreas, liver, and heart) may have important implications to risk factors associated with the metabolic syndrome. Imbalance of ERα/ERβ ratio in this “metabolic network” may lead to the metabolic syndrome. The metabolic syndrome has reached pandemic level worldwide, and evidence is that estradiol plays a key role in its development. The discovery of the second estrogen receptor, ERβ, in tissues previously not considered targets of estradiol was a breakthrough in endocrinology. In the present review, we discuss how the presence of ERβ and the previously described ERα in tissues involved in glucose and lipid homeostasis (brain, skeletal muscle, adipose tissue, pancreas, liver, and heart) may have important implications to risk factors associated with the metabolic syndrome. Imbalance of ERα/ERβ ratio in this “metabolic network” may lead to the metabolic syndrome." @default.
- W2065683049 created "2016-06-24" @default.
- W2065683049 creator A5026369302 @default.
- W2065683049 creator A5085801141 @default.
- W2065683049 date "2011-09-01" @default.
- W2065683049 modified "2023-10-15" @default.
- W2065683049 title "Estrogen Receptors and the Metabolic Network" @default.
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