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• W2065683860 endingPage "803" @default.
• W2065683860 startingPage "791" @default.
• W2065683860 abstract "Background: The polypeptide anthopleurin-B (AP-B) is one of a number of related toxins produced by sea anemones. AP-B delays inactivation of the voltage-gated sodium channel of excitable tissue. In the mammalian heart, this effect is manifest as an increase in the force of contraction. As a result, there is interest in exploiting the anthopleurins as lead compounds in the design of novel cardiac stimulants. Essential to this endeavour is a high-resolution solution structure of the molecule describing the positions of functionally important side chains.Results AP-B exists in multiple conformations in solution as a result of cis–trans isomerization about the Gly40–Pro41 peptide bond. The solution structure of the major conformer of AP-B has been determined by two-dimensional 1H NMR at pH 4.5 and 25°C. The core structure is a four-stranded, antiparallel β-sheet (residues 2–4, 20–23, 34–37 and 45–48) and includes several β-turns (6–9, 25–28, 30–33). Three loops connect the β-strands, the longest and least well defined being the first loop, extending from residues 8–17. These features are shared by other members of this family of sea anemone toxins. The locations of a number of side chains which are important for the cardiac stimulatory activity of AP-B are well defined in the structures.Conclusion We have described the solution structure of AP-B and compared it with that of AP-A, from which it differs by substitutions at seven amino acid positions. It shares an essentially identical fold with AP-A yet is about 10-fold more active. Comparison of the structures, particularly in the region of residues essential for activity, gives a clearer indication of the location and extent of the cardioactive pharmacophore in these polypeptides." @default.
• W2065683860 created "2016-06-24" @default.
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• W2065683860 date "1995-08-01" @default.
• W2065683860 modified "2023-10-03" @default.
• W2065683860 title "Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A" @default.
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• W2065683860 doi "https://doi.org/10.1016/s0969-2126(01)00214-3" @default.
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