Matches in SemOpenAlex for { <https://semopenalex.org/work/W2065685736> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2065685736 endingPage "24" @default.
- W2065685736 startingPage "17" @default.
- W2065685736 abstract "To develop a reliable experimental model of vascular headache, we studied the dose-response relationship between headache and i.v. nitroglycerin (NTG) in 10 healthy subjects. NTG was infused intravenously over periods of 10 min separated by wash-out periods. Doses of 0.25, 0.50, 1.00 and 2.00 μg/kg/min were applied successively with one placebo infusion and wash-out period inserted randomly and double blindly. The subjects scored their headache intensity on a scale 0–10. After 1–8 weeks a retest was performed. Nine subjects developed headache already at 0.25 μg/kg/min, whereas one had no headache at any dose. Headache severity did not increase with doses above 0.5 μg/kg/min. This ceiling effect was reproducible. The headache was moderate, usually throbbing, bifrontal and not associated with other migrainous features. It reached maximum within 2.5–5.5 min (medians) at various doses and declined rapidly after NTG discontinuation. Wash-out periods of 10–20 min were sufficient. The reproducibility of headache intensity and character was satisfactory in the retest experiment. There were no unpleasant side effects and no visible flushing. Thus blindness was maintained. I.v. NTG is suitable as an experimental headache model. A constant infusion of 0.5 μ/kg/min will be suitable for studies of arterial diameter, pulsations, blood flow, etc. Comparative studies of sensitivity should use the present infusion schedule but with the two highest doses substituted by 0.06 and 0.125 μg/kg/min." @default.
- W2065685736 created "2016-06-24" @default.
- W2065685736 creator A5038961547 @default.
- W2065685736 creator A5044870456 @default.
- W2065685736 creator A5057969496 @default.
- W2065685736 date "1989-07-01" @default.
- W2065685736 modified "2023-09-25" @default.
- W2065685736 title "Intravenous nitroglycerin as an experimental model of vascular headache. Basic characteristics" @default.
- W2065685736 cites W1991143553 @default.
- W2065685736 cites W1992842279 @default.
- W2065685736 cites W2014757195 @default.
- W2065685736 cites W2016422927 @default.
- W2065685736 cites W2018137947 @default.
- W2065685736 cites W2018522824 @default.
- W2065685736 cites W2027795141 @default.
- W2065685736 cites W2032181779 @default.
- W2065685736 cites W2039780770 @default.
- W2065685736 cites W2056621719 @default.
- W2065685736 cites W2061529241 @default.
- W2065685736 cites W2071073846 @default.
- W2065685736 cites W2088884950 @default.
- W2065685736 cites W2094889906 @default.
- W2065685736 cites W2095003120 @default.
- W2065685736 doi "https://doi.org/10.1016/0304-3959(89)90067-5" @default.
- W2065685736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2506503" @default.
- W2065685736 hasPublicationYear "1989" @default.
- W2065685736 type Work @default.
- W2065685736 sameAs 2065685736 @default.
- W2065685736 citedByCount "327" @default.
- W2065685736 countsByYear W20656857362012 @default.
- W2065685736 countsByYear W20656857362013 @default.
- W2065685736 countsByYear W20656857362014 @default.
- W2065685736 countsByYear W20656857362015 @default.
- W2065685736 countsByYear W20656857362016 @default.
- W2065685736 countsByYear W20656857362017 @default.
- W2065685736 countsByYear W20656857362018 @default.
- W2065685736 countsByYear W20656857362019 @default.
- W2065685736 countsByYear W20656857362020 @default.
- W2065685736 countsByYear W20656857362021 @default.
- W2065685736 countsByYear W20656857362022 @default.
- W2065685736 countsByYear W20656857362023 @default.
- W2065685736 crossrefType "journal-article" @default.
- W2065685736 hasAuthorship W2065685736A5038961547 @default.
- W2065685736 hasAuthorship W2065685736A5044870456 @default.
- W2065685736 hasAuthorship W2065685736A5057969496 @default.
- W2065685736 hasConcept C141071460 @default.
- W2065685736 hasConcept C142724271 @default.
- W2065685736 hasConcept C191290158 @default.
- W2065685736 hasConcept C204787440 @default.
- W2065685736 hasConcept C27081682 @default.
- W2065685736 hasConcept C2778715236 @default.
- W2065685736 hasConcept C42219234 @default.
- W2065685736 hasConcept C71924100 @default.
- W2065685736 hasConceptScore W2065685736C141071460 @default.
- W2065685736 hasConceptScore W2065685736C142724271 @default.
- W2065685736 hasConceptScore W2065685736C191290158 @default.
- W2065685736 hasConceptScore W2065685736C204787440 @default.
- W2065685736 hasConceptScore W2065685736C27081682 @default.
- W2065685736 hasConceptScore W2065685736C2778715236 @default.
- W2065685736 hasConceptScore W2065685736C42219234 @default.
- W2065685736 hasConceptScore W2065685736C71924100 @default.
- W2065685736 hasIssue "1" @default.
- W2065685736 hasLocation W20656857361 @default.
- W2065685736 hasOpenAccess W2065685736 @default.
- W2065685736 hasPrimaryLocation W20656857361 @default.
- W2065685736 hasRelatedWork W1561228767 @default.
- W2065685736 hasRelatedWork W1981172430 @default.
- W2065685736 hasRelatedWork W2016666848 @default.
- W2065685736 hasRelatedWork W2040977256 @default.
- W2065685736 hasRelatedWork W2121438713 @default.
- W2065685736 hasRelatedWork W2281136931 @default.
- W2065685736 hasRelatedWork W2466043692 @default.
- W2065685736 hasRelatedWork W3049345570 @default.
- W2065685736 hasRelatedWork W4233016836 @default.
- W2065685736 hasRelatedWork W2978363241 @default.
- W2065685736 hasVolume "38" @default.
- W2065685736 isParatext "false" @default.
- W2065685736 isRetracted "false" @default.
- W2065685736 magId "2065685736" @default.
- W2065685736 workType "article" @default.