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- W2065687653 abstract "Adhesion between lymphocytes and other cells is critical to many processes in the normal immune system. Alteration in the expression of cell adhesion molecules may be important in determining the behaviour of malignant lymphomas. In this study, the adhesion of normal lymphocytes to fibroblasts is compared with the adhesion of the T-cell lymphomas J6 and Hut78 ICRF. J6 was significantly more adherent to fibroblasts than either Hut 78 or PBL despite the fact that J6 expresses almost no LFA-1. Anti-LFA-1 had little effect on the basal adhesion of Hut 78 ICRF or PBL. Addition of anti-CD2 caused enhanced adhesion of J6 and PBL but not Hut 78ICRF, which expresses little of this molecule. This enhancement was abrogated by anti-LFA-1. Anti-CD45 also caused enhanced adhesion of PBL. This was largely due to LFA-1-mediated homotypic cell adhesion. The tumour cell lines display no such homotypic adhesion and the small enhancement of fibroblast adhesion was much less affected by the anti-LFA-1 antibody. These results show the complex interactions which occur between adhesion molecules and that differences in patterns of expression between normal and neoplastic cells could be a major determinant of tumour cell behaviour." @default.
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- W2065687653 date "1991-06-01" @default.
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- W2065687653 title "Adhesion of normal and neoplastic lymphoid cells to fibroblasts" @default.
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- W2065687653 doi "https://doi.org/10.1002/path.1711640209" @default.
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